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活体人类大脑侧脑室的MRI三维成像:形态学及形态计量学与年龄、性别相关性的初步研究

MRI 3D lateral cerebral ventricles in living humans: morphological and morphometrical age-, gender-related preliminary study.

作者信息

Trimarchi Fabio, Bramanti Placido, Marino Silvia, Milardi Demetrio, Di Mauro Debora, Ielitro Giuseppe, Valenti Barbara, Vaccarino Gianluigi, Milazzo Carmelo, Cutroneo Giuseppina

机构信息

Department of Biomorphology and Biotechnologies, University of Messina, Messina, Italy.

出版信息

Anat Sci Int. 2013 Mar;88(2):61-9. doi: 10.1007/s12565-012-0162-x. Epub 2012 Nov 20.

DOI:10.1007/s12565-012-0162-x
PMID:23179909
Abstract

Morphological and volumetric variabilities of lateral ventricles are considered indirect indicators of age-and gender-related reductions of white and gray matter. However, no studies have classified lateral ventricles with different morphologies or showed its asymmetric shapes in healthy subjects. We performed an analysis on living subjects, using 3D volume rendering techniques. Eighty-five healthy Caucasian volunteers (49 women and 36 men aged 19-69 years) were scanned by a Philips Achieva 3T R2.6. Three-dimensional reconstruction allowed us to identify three main morphological shapes in living subjects and to show asymmetries between horns. We also assessed the surface deformation of the cerebral ventricles to identify region-specific shape differences in aging healthy adults. Statistical analysis showed significant gender- and age-related volume differences. An increase in lateral ventricle volume appears to be a constant, linear function of age throughout adult life.

摘要

侧脑室的形态和容积变异性被认为是与年龄和性别相关的白质和灰质减少的间接指标。然而,尚无研究对健康受试者中不同形态的侧脑室进行分类或展示其不对称形状。我们使用3D容积再现技术对活体受试者进行了分析。85名健康的高加索志愿者(49名女性和36名男性,年龄在19至69岁之间)接受了飞利浦Achieva 3T R2.6扫描仪的扫描。三维重建使我们能够识别活体受试者中的三种主要形态,并展示角之间的不对称性。我们还评估了脑室的表面变形,以识别健康老年成年人中特定区域的形状差异。统计分析显示存在显著的性别和年龄相关的容积差异。在整个成年期,侧脑室容积的增加似乎是年龄的恒定线性函数。

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