Unit of Psychiatry, Department of Neurosciences, University of Messina, Italy.
Psychiatry Res. 2010 Jul 30;183(1):52-8. doi: 10.1016/j.pscychresns.2010.01.014. Epub 2010 Jun 9.
The goal of this report was to highlight lateral ventricle morphology and volume differences between schizophrenia patients and matched controls. Subjects identified as suitable for analysis comprised 15 schizophrenia patients and 15 healthy subjects. The method applied is three-dimensional (3D) volume rendering starting from structural magnetic resonance imaging (MRI) studies of selected ventricular regions. Differences between groups relative to the global ventricular system and its subdivisions were found. Total lateral ventricle volume, right ventricle volume and left ventricle volume were all higher in schizophrenia patients than in controls; unilateral differences between the two groups were also outlined (right ventricle volume>left ventricle volume in schizophrenia patients vs. healthy subjects). Furthermore, occipital and frontal horn enlargement was found in schizophrenia patients compared with normal controls, but the difference in the temporal horn was not statistically significant. A substantial difference was noted in lateral ventricle morphology between the two groups. Our findings were consistent with the literature and may shed light on some of the discrepancies in previous reports on differences in lateral ventricle volume enlargement.
本报告旨在强调精神分裂症患者与匹配对照者之间侧脑室形态和容积的差异。确定适合分析的受试者包括 15 名精神分裂症患者和 15 名健康受试者。所应用的方法是基于对选定脑室区域的结构磁共振成像 (MRI) 研究的三维 (3D) 容积渲染。发现组间相对于整个脑室系统及其细分的差异。与对照组相比，精神分裂症患者的总侧脑室容积、右心室容积和左心室容积均较高；两组之间也存在单侧差异（精神分裂症患者的右心室容积>左心室容积，而健康受试者则相反）。此外，与正常对照组相比，精神分裂症患者的枕角和额角扩大，但颞角的差异无统计学意义。两组之间的侧脑室形态存在显著差异。我们的研究结果与文献一致，可能有助于解释先前关于侧脑室容积扩大差异的报告中的一些差异。
