Autonomic Function Laboratory, Division of Neurobiology, Department of Neurology, Innsbruck Medical University, Anichstrasse 35, Innsbruck, Austria.
J Neurol. 2013 Sep;260(9):2212-9. doi: 10.1007/s00415-012-6736-7. Epub 2012 Nov 20.
Neurogenic orthostatic hypotension is a distinctive and treatable sign of cardiovascular autonomic dysfunction. It is caused by failure of noradrenergic neurotransmission that is associated with a range of primary or secondary autonomic disorders, including pure autonomic failure, Parkinson's disease with autonomic failure, multiple system atrophy as well as diabetic and nondiabetic autonomic neuropathies. Neurogenic orthostatic hypotension is commonly accompanied by autonomic dysregulation involving other organ systems such as the bowel and the bladder. In the present review, we provide an overview of the clinical presentation, pathophysiology, epidemiology, evaluation and management of neurogenic orthostatic hypotension focusing on neurodegenerative disorders.
神经源性直立性低血压是心血管自主功能障碍的一种独特且可治疗的征象。它是由去甲肾上腺素能神经传递失败引起的，与一系列原发性或继发性自主神经紊乱有关，包括单纯自主神经衰竭、帕金森病伴自主神经衰竭、多系统萎缩以及糖尿病和非糖尿病自主神经病变。神经源性直立性低血压通常伴有涉及其他器官系统的自主调节障碍，如肠道和膀胱。在本综述中，我们重点介绍神经退行性疾病，概述了神经源性直立性低血压的临床表现、病理生理学、流行病学、评估和治疗。
