CNRS, LCC (Laboratoire de Chimie de Coordination), 205 route de Narbonne, BP 44099, 31077 Toulouse Cedex 4, France.
Chemistry. 2012 Dec 7;18(50):15910-20. doi: 10.1002/chem.201202697. Epub 2012 Nov 23.
Metal ions Cu, Zn and Fe, seem to play a pivotal role in Alzheimer's disease and other neurodegenerative diseases. In order to understand this in a broader sense, one has to considerer the peculiarities of metal metabolism in the brain compared to most other tissues, as well as the importance of the redox active metal ions, Fe and Cu, in oxygen metabolism and the connected oxidative stress.
金属离子 Cu、Zn 和 Fe 似乎在阿尔茨海默病和其他神经退行性疾病中起着关键作用。为了更广泛地理解这一点，人们必须考虑到与大多数其他组织相比，大脑中金属代谢的特殊性，以及具有氧化还原活性的金属离子 Fe 和 Cu 在氧代谢和相关氧化应激中的重要性。
Zotero 插件