Department of Medical Biotechnology, Yeungnam University, Gyeongsan, South Korea.
Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, P.O. Box 173, Al-Kharj 11942, Saudi Arabia.
Curr Neuropharmacol. 2021;19(11):1884-1895. doi: 10.2174/1570159X19666210215122333.
Alzheimer's disease (AD) affects several people worldwide and has devastating impacts on society with a limited number of approaches for its pharmacological treatment. The main causes of AD are not clear yet. However, the formation of senile plaques, neurofibrillary tangles, hyper-phosphorylation of tau protein, and disruption of redox homeostasis may cause AD. These causes have a positive correlation with oxidative stress, producing reactive ions, which are responsible for altering the physiological condition of the body.
Ongoing research recommended the use of phytochemicals as acetylcholinesterase inhibitors to hinder the onset and progression of AD. The natural compound structures, including lignans, flavonoids, tannins, polyphenols, triterpenes, sterols, and alkaloids have anti-inflammatory, antioxidant, and anti-amyloidogenic properties. The purpose of this article is to provide a brief introduction to AD along with the use of natural compounds as new therapeutic approaches for its management.
阿尔茨海默病（AD）影响着全球的许多人，其在社会上造成了破坏性影响，而针对其的药物治疗方法却十分有限。AD 的主要病因尚不清楚。然而，老年斑的形成、神经原纤维缠结、tau 蛋白过度磷酸化以及氧化还原平衡的破坏可能导致 AD。这些原因与氧化应激呈正相关，产生反应离子，这会导致身体的生理状况发生改变。
正在进行的研究建议使用植物化学物质作为乙酰胆碱酯酶抑制剂，以阻止 AD 的发生和发展。天然化合物结构，包括木脂素、类黄酮、单宁、多酚、三萜、甾醇和生物碱，具有抗炎、抗氧化和抗淀粉样变性的特性。本文的目的是简要介绍 AD 并讨论将天然化合物用作其管理的新治疗方法。
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