Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
Molecules. 2023 Jul 17;28(14):5467. doi: 10.3390/molecules28145467.
Metal ions are fundamental to guarantee the regular physiological activity of the human organism. Similarly, vitamins play a key role in many biological functions of the metabolism, among which are coenzymes, redox mediators, and antioxidants. Due to their importance in the human organism, both metals and vitamins have been extensively studied for their involvement in neurodegenerative diseases (NDs). However, the full potential of the interaction between vitamins and metal ions has not been fully explored by researchers yet, and further investigation on this topic is needed. The aim of this review is to provide an overview of the scientific literature on the implications of vitamins and selected metal ions in two of the most common neurodegenerative diseases, Alzheimer's and Parkinson's disease. Furthermore, vitamin-metal ion interactions are discussed in detail focusing on their bioinorganic chemistry, with the perspective of arousing more interest in this fascinating bioinorganic field.
金属离子是保证人体正常生理活动的基础。同样，维生素在新陈代谢的许多生物功能中起着关键作用，其中包括辅酶、氧化还原介质和抗氧化剂。由于它们在人体中的重要性，金属和维生素都因其与神经退行性疾病（NDs）的关系而被广泛研究。然而，研究人员尚未充分探索维生素和金属离子之间相互作用的全部潜力，因此需要对此课题进行进一步研究。本文综述的目的是概述关于维生素和两种最常见的神经退行性疾病（阿尔茨海默病和帕金森病）中选定金属离子的科学文献。此外，还详细讨论了维生素-金属离子相互作用，重点关注它们的生物无机化学，以期激发人们对这个迷人的生物无机领域产生更多的兴趣。
