通过铱催化的不对称烯丙基烷基化反应和分子内 Diels-Alder 反应的组合，合成了吲达霉素和司他霉素的六氢茚核心。
Syntheses of the hexahydroindene cores of indanomycin and stawamycin by combinations of iridium-catalyzed asymmetric allylic alkylations and intramolecular Diels-Alder reactions.
机构信息
Organisch-Chemisches Institut, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany.
出版信息
Chemistry. 2013 Jan 2;19(1):400-5. doi: 10.1002/chem.201202822. Epub 2012 Nov 23.
PMID:23180592
Abstract
Short and concise syntheses of the hexahydroindene cores of the antibiotics indanomycin (X-14547 A) and stawamycin are presented. Key methods used are an asymmetric iridium-catalyzed allylic alkylation, a modified Julia olefination, a Suzuki-Miyaura coupling, and an intramolecular Diels-Alder reaction.
摘要
介绍了抗生素吲达霉素（X-14547A）和斯塔霉素的六氢茚核心的简短而简洁的合成。所使用的关键方法是不对称铱催化的烯丙基烷基化、改良的 Julia 烯丙基化、Suzuki-Miyaura 偶联和分子内 Diels-Alder 反应。
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