Hou Li-Na, Li Fei, Zhou You, Nie Shi-Huai, Su Liang, Chen Ping-An, Tan Wan-Long, Xu Ding-Li
Departments of Cardiology and.
Exp Ther Med. 2012 Sep;4(3):481-486. doi: 10.3892/etm.2012.605. Epub 2012 Jun 8.
The findings on the association between fish intake and the risk of heart failure (HF) have been inconsistent. The purpose of this study was to clarify this potential association. We searched for relevant studies in the PubMed database through January 2012 and manually reviewed references. Five independent prospective cohort studies involving 5,273 cases and 144,917 participants were included. The summary relative risk estimates (SRRE) based on the highest compared with the lowest category of fish consumption were estimated by variance-based meta-analysis. In addition, we performed sensitivity and dose-response analyses to examine the association. Overall, an absence of an association between fish intake and HF was observed (SRRE=1.00; 95% CI, 0.81-1.24). However, fried fish intake positively associated with HF (SRRE=1.40; 95% CI, 1.22-1.61). In addition, dose-response analysis of fried fish suggested that each increment of six fried fish per month corresponded to a 37% increase of HF rate (RR=1.37; 95% CI, 1.20-1.56). In conclusion, our findings suggest that there is no significant association between fish intake and risk of HF, with the exception of a possible positive correlation with individuals comsuming fried fish, based on a limited number of studies. Future studies are required to confirm these findings.
鱼类摄入量与心力衰竭（HF）风险之间的关联研究结果并不一致。本研究的目的是阐明这种潜在关联。我们在PubMed数据库中检索截至2012年1月的相关研究，并人工查阅参考文献。纳入了五项独立的前瞻性队列研究，涉及5273例病例和144917名参与者。通过基于方差的荟萃分析估计了鱼类消费量最高类别与最低类别相比的汇总相对风险估计值（SRRE）。此外，我们进行了敏感性和剂量反应分析以检验这种关联。总体而言，未观察到鱼类摄入量与HF之间存在关联（SRRE=1.00；95%CI，0.81-1.24）。然而，油炸鱼类摄入量与HF呈正相关（SRRE=1.40；95%CI，1.22-1.61）。此外，对油炸鱼类的剂量反应分析表明，每月每增加六条油炸鱼，HF发生率增加37%（RR=1.37；95%CI，1.20-1.56）。总之，基于有限数量的研究，我们的研究结果表明，除了食用油炸鱼的个体可能存在正相关外，鱼类摄入量与HF风险之间没有显著关联。需要进一步的研究来证实这些发现。
