鳞状细胞癌和基底细胞癌的无创光学检测初步研究。
Preliminary study for non - invasive optical detection of squamous and basal cell carcinomas.
机构信息
College of Engineering, Medical Engineering Department, Al-Nahrain University, Baghdad, Iraq.
出版信息
Biomed Eng Online. 2012 Nov 26;11:88. doi: 10.1186/1475-925X-11-88.
BACKGROUND
The early detection of skin cancer may highly increase the chances of its healing. One of the non-invasive methods of such detection based on the Oblique- Incidence Diffuse Reflectance (OIDR) measurements of the reflected diode laser light from the skin. In this research we designed and implemented the OIDR reflectometry measuring system with a 650 nm diode laser source to aid physicians in diagnosing both squamous cell carcinomas (SCC) and basal cell carcinomas(BCC).
METHOD
The laser is delivered obliquely to the skin surface by an optical fiber fitted through a tube holder of CCD camera. The diffused reflected laser light from the skin is captured by the CCD camera and sent to a computer, which is supplied by a specially prepared Matlab program to analyze these images in order to decide in a time whether the lesion is malignant or benign. Fifty cases were diagnosed under supervision of the consultant section of The Governmental Specialized Marjan Teaching Hospital - MOH - Iraq.
RESULT
The fifty diagnosed cases by this technique, the results were 90% accurate.
CONCLUSION
The method of laser oblique-incidence diffuse reflectance (OIDR) combined with using the developed algorithms that have high classification rates may prove useful in the clinic as the process is fast, noninvasive and accurate.
背景
皮肤癌的早期检测可以大大提高治愈的机会。这种检测的非侵入性方法之一是基于皮肤反射二极管激光的斜向漫反射（OIDR）测量。在这项研究中，我们设计并实现了一种 OIDR 反射测量系统，使用 650nm 二极管激光源，以帮助医生诊断鳞状细胞癌（SCC）和基底细胞癌（BCC）。
方法
激光通过光纤斜向传输到皮肤表面，光纤安装在 CCD 相机的管架上。皮肤的漫反射激光光由 CCD 相机捕获，并发送到计算机，计算机由专门编写的 Matlab 程序提供，以分析这些图像，以便及时判断病变是恶性还是良性。在伊拉克政府专门化马赞教学医院 - MOH - 顾问科室的监督下，对五十例病例进行了诊断。
结果
通过这种技术诊断的五十例病例，准确率为 90%。
结论
激光斜向漫反射（OIDR）方法结合使用具有高分类率的开发算法，可能在临床上证明是有用的，因为该过程快速、非侵入性和准确。
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