利用斜入射漫反射光谱技术对包括黑色素瘤在内的色素性皮肤病变的光学特性进行体内分析。
In-vivo characterization of optical properties of pigmented skin lesions including melanoma using oblique incidence diffuse reflectance spectrometry.
出版信息
J Biomed Opt. 2011 Feb;16(2):020501. doi: 10.1117/1.3536509.
Abstract
In this letter, we report the first use of oblique incidence diffuse reflectance spectrometry to conduct in-vivo measurements of optical properties of three different types of pigmented skin lesions, including melanoma, dysplastic, and common nevi. Both absorption and reduced scattering coefficient spectra were estimated from the spatially resolved diffuse reflectance within the wavelength range of 455-765 nm for 144 pigmented skin lesions including 16 melanomas. The absorption and reduced scattering spectra were found to change with the malignancy of the skin lesions, which were generally higher for the malignant cases than the benign ones. Based on the measurement results, the physiological origin leading to the change of the absorption and scattering properties is also discussed.
摘要
在这封信中，我们报告了首次使用斜入射漫反射光谱技术对三种不同类型的色素性皮肤病变（包括黑色素瘤、发育不良和常见痣）进行体内光学特性测量。在 455-765nm 的波长范围内，对包括 16 个黑色素瘤在内的 144 个色素性皮肤病变的空间分辨漫反射，我们估计了吸收和降低散射系数光谱。发现吸收和降低散射光谱随皮肤病变的恶性程度而变化，恶性病例的吸收和散射特性通常高于良性病例。基于测量结果，还讨论了导致吸收和散射特性变化的生理起源。
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