School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK.
Chem Commun (Camb). 2013 Feb 21;49(15):1521-3. doi: 10.1039/c2cc38944d.
We report efficient Pd-catalyzed cyclizations of oxime esters with 1,1-disubstituted alkenes as the basis of a general entry to α,α-disubstituted pyrrolidine derivatives. We also demonstrate that catalytic asymmetric variants of this chemistry are feasible by employing a suitable chiral ligand.
我们报道了以肟酯与 1,1-二取代烯烃的环化为基础的高效钯催化反应，为α,α-二取代吡咯烷衍生物提供了一种通用的合成方法。我们还通过使用合适的手性配体证明了这种化学的催化不对称变体是可行的。
