Genetic Group, Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran.
Cancer Sci. 2013 Jan;104(1):28-35. doi: 10.1111/cas.12074. Epub 2012 Dec 31.
The epithelial to mesenchymal transition (EMT), a pathologic phenomenon in cancer, has a twin in the embryonic period of life. In the first one, its promotion will cause metastasis to become a life-threatening stage of cancer, while in the second it will lead to organogenesis, which is necessary for all living creatures. There is one more from this phenomenon, which occurs during the wound healing process and if dys-regulated can lead to fibrosis. In both there are stimulants in common and one that are different. Stages start from cell-cell junction dissociation followed by morphological changes and behavioral and essence alterations. To control the EMT as a bizarre disturbance in cancer and metastasis, initially it is better to understand the wonder of natural gestational orchestration in early life. In this review, first the structure of the two heads of the spectrum is described followed by the cellular and micro-environmental alterations during this phenomenon. Understanding cellular behavior in this process and what makes them invasive resistant stemness cells will be of great importance in highlighting roads to cancer treatment.
上皮-间充质转化（EMT）是癌症中的一种病理现象，它在生命的胚胎期也有一个对应物。在前者中，它的促进将导致转移成为癌症的致命阶段，而在后者中，它将导致器官发生，这是所有生物所必需的。这种现象还有一个，它发生在伤口愈合过程中，如果失调可能导致纤维化。在这两种情况下，都有共同的刺激因素和不同的因素。阶段从细胞-细胞连接分离开始，随后是形态变化以及行为和本质的改变。为了控制 EMT 作为癌症和转移中的奇异干扰，最初最好了解早期生命中自然妊娠协调的奇妙之处。在这篇综述中，首先描述了这一现象的两个方面的结构，然后描述了细胞和微环境在这一现象中的改变。了解这个过程中的细胞行为以及是什么使它们具有侵袭性、耐药性和干细胞特性，将对突出癌症治疗途径具有重要意义。
