Sree Siddaganga College of Pharmacy, Tumkur, Karnataka 572 102, India.
J Ethnopharmacol. 2013 Jan 9;145(1):363-72. doi: 10.1016/j.jep.2012.11.023. Epub 2012 Nov 23.
Chromolaena odorata Linn., is used in traditional Indian medicine in the treatment of diabetes and eye problems.
The present study was designed to investigate the effect of the ethanol extract Chromolaena odorata leaves (ACO) in streptozotocin (STZ; 45 mg/kg, i.v) induced diabetes and cataract in rats.
Different doses of ACO (200 and 400mg/kg) was administered once daily for eight weeks to STZ-induced diabetic rats. To know the mechanism of action of title plant, AUC(glucose), AUC(insulin), Homeostatic Model Assessment (HOMA), insulin tolerance test (ITT) and glucose uptake by rat hemi-diaphragms were carried out. Further, cataract score was taken once in a week upto eight weeks and opacity index was measured. HPLC fingerprinting profiling of ACO was also carried out.
Administration of ACO exhibited significant reduction in glucose, HOMA, lipid profiles and significantly improved glucose and insulin tolerance, glycogen content, glucose uptake by skeletal muscle, serum insulin and HDL-c levels. In addition, ACO also decreased oxidative stress by improving endogenous antioxidants. Further, treatment of ACO showed significantly reduced onset and extent of cataract.
The present data suggested that the treatment of ACO reversed the STZ-induced diabetes and cataract in rats. The observed beneficial effects may be mediated by interacting with multiple targets operating in diabetes mellitus and its complication. Taken together, this study provided the scientific evidence for the traditional use of Chromolaena odorata.
臭娘子，被用于传统的印度医学治疗糖尿病和眼部问题。
本研究旨在研究乙醇提取物臭娘子叶（ACO）对链脲佐菌素（STZ；45mg/kg，iv）诱导的糖尿病和大鼠白内障的影响。
不同剂量的 ACO（200 和 400mg/kg）每天一次给予 STZ 诱导的糖尿病大鼠 8 周。为了了解标题植物的作用机制，进行了 AUC（葡萄糖）、AUC（胰岛素）、稳态模型评估（HOMA）、胰岛素耐量试验（ITT）和大鼠半膈肌葡萄糖摄取。此外，每周一次记录白内障评分，直至 8 周，并测量不透明度指数。还对 ACO 进行了 HPLC 指纹图谱分析。
ACO 的给药显著降低了葡萄糖、HOMA、血脂谱，并显著改善了葡萄糖和胰岛素耐量、糖原含量、骨骼肌葡萄糖摄取、血清胰岛素和高密度脂蛋白胆固醇水平。此外，ACO 还通过改善内源性抗氧化剂来降低氧化应激。此外，ACO 的治疗还显著降低了白内障的发生和程度。
目前的数据表明，ACO 的治疗逆转了 STZ 诱导的糖尿病和大鼠白内障。观察到的有益效果可能是通过与糖尿病及其并发症中多个作用靶点相互作用介导的。综上所述，这项研究为臭娘子的传统用途提供了科学依据。
