Department of Biobehavioral Health, Pennsylvania State University, State College, PA 16801, USA.
Am J Med Genet B Neuropsychiatr Genet. 2013 Jan;162B(1):61-70. doi: 10.1002/ajmg.b.32122. Epub 2012 Nov 26.
Major depressive disorder (MDD) is a complex psychiatric condition with strong genetic predisposition. The association of MDD with genetic polymorphisms, such as Val66Met (rs6265), in the brain derived neurotrophic factor (BDNF), have been reported in many studies and the results were conflicting. In this study, we performed a systematic literature search and conducted random-effects meta-analysis to evaluate genetic variants in BDNF with MDD. A gene-based analysis was also conducted to investigate the cumulative effects of genetic polymorphisms in BDNF. A total of 28 studies from 26 published articles were included in our analysis. Meta-analysis yielded an estimated odds ratio (OR) of 0.96 (95% CI: 0.89-1.05; P = 0.402) for Val66Met (rs6265), 0.83 (95% CI: 0.67-1.04; P = 0.103) for 11757C/G, 1.16 (95% CI: 0.74-1.82; P = 0.527) for 270T/C, 1.03 (95% CI: 0.18-5.75; P = 0.974) for 712A/G and 0.98 (95% CI: 0.85-1.14; P = 0.831) for rs988748. The gene-based analysis indicated that BDNF is not associated with MDD (P > 0.21). Our updated meta- and novel gene-based analyses provide no evidence of the association of BDNF with major depression.
重度抑郁症（MDD）是一种具有强烈遗传倾向的复杂精神疾病。许多研究报道了 MDD 与脑源性神经营养因子（BDNF）中的遗传多态性，如 Val66Met（rs6265）之间的关联，但其结果存在争议。在这项研究中，我们进行了系统的文献检索，并进行了随机效应荟萃分析，以评估 BDNF 中的遗传变异与 MDD 的关系。我们还进行了基于基因的分析，以研究 BDNF 遗传多态性的累积效应。共有 28 项研究，来自 26 篇已发表的文章，被纳入我们的分析。荟萃分析得出，Val66Met（rs6265）的估计比值比（OR）为 0.96（95%CI：0.89-1.05；P = 0.402），11757C/G 的 OR 为 0.83（95%CI：0.67-1.04；P = 0.103），270T/C 的 OR 为 1.16（95%CI：0.74-1.82；P = 0.527），712A/G 的 OR 为 1.03（95%CI：0.18-5.75；P = 0.974），rs988748 的 OR 为 0.98（95%CI：0.85-1.14；P = 0.831）。基于基因的分析表明，BDNF 与 MDD 无关（P > 0.21）。我们的更新的荟萃分析和新的基于基因的分析均未提供 BDNF 与重度抑郁症相关的证据。
