College of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, China.
Mol Biol Rep. 2012 May;39(5):5691-8. doi: 10.1007/s11033-011-1377-y. Epub 2011 Dec 22.
The objective of this study was to examine the effect of genetic variants in fat mass and obesity associated (FTO) gene on metabolic syndrome (MetS). A systematic literature search was performed and random-effects meta-analysis was used to evaluate genetic variants in FTO with MetS. A gene-based analysis was conducted to investigate the cumulative effects of genetic polymorphisms in FTO. A total of 18 studies from 13 published papers were included in our analysis. Random-effects meta-analysis yielded an estimated odds ratio of 1.19 (95% CI 1.12-1.27; P = 1.38 × 10(-7)) for rs9939609, 1.19 (95% CI 1.05-1.35; P = 0.008) for rs8050136, and 1.89 (95% CI 1.20-2.96; P = 0.006) for rs1421085. The gene-based analysis indicated that FTO is strongly associated with MetS (P < 10(-5)). This association remains after excluding rs9939609, a SNP that was frequently reported to have strong association with obesity and MetS. In this study, we concluded that the FTO gene may play a critical role in leading to MetS. Targeting this gene may provide novel therapeutic strategies for the prevention and treatment of metabolic syndrome.
本研究旨在探讨脂肪量和肥胖相关基因（FTO）基因的遗传变异对代谢综合征（MetS）的影响。进行了系统的文献检索，并采用随机效应荟萃分析来评估 FTO 基因中的遗传变异与 MetS 的关系。进行了基于基因的分析，以研究 FTO 中遗传多态性的累积效应。我们的分析共纳入了 13 篇已发表文献中的 18 项研究。随机效应荟萃分析得出 rs9939609 的估计比值比为 1.19（95%CI 1.12-1.27；P=1.38×10(-7)），rs8050136 为 1.19（95%CI 1.05-1.35；P=0.008），rs1421085 为 1.89（95%CI 1.20-2.96；P=0.006）。基于基因的分析表明，FTO 与 MetS 密切相关（P<10(-5)）。排除与肥胖和 MetS 密切相关的 SNP rs9939609 后，这种相关性仍然存在。本研究表明，FTO 基因可能在导致 MetS 方面发挥关键作用。针对该基因可能为代谢综合征的预防和治疗提供新的治疗策略。
