Departments of Biomedical Engineering and Orthopedics & Rehabilitation, University of Wisconsin, 5009 Wisconsin Institutes of Medical Research, 1111 Highland Ave., Madison, WI 53705, USA.
Adv Healthc Mater. 2012 Jul;1(4):457-60. doi: 10.1002/adhm.201200077. Epub 2012 May 11.
VEGF-binding peptide ligands are incorporated into hydrogel microspheres and reduce the amount of growth factor in solution. VEGF binding affinity is enhanced by creating ligands with a dimer structure. The spheres are able to knock down VEGF-mediated HUVEC growth and reduce calcium signaling. The binding interaction is reversible, allowing the spheres to be used as a VEGF delivery vehicle.
VEGF 结合肽配体被整合到水凝胶微球中，从而减少溶液中生长因子的含量。通过构建具有二聚体结构的配体可以增强 VEGF 结合亲和力。这些球体能够抑制 VEGF 介导的 HUVEC 生长并减少钙信号转导。结合相互作用是可逆的，允许球体用作 VEGF 递送载体。
