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DOBISCUIT：次生代谢产物生物合成基因簇数据库。

DoBISCUIT: a database of secondary metabolite biosynthetic gene clusters.

机构信息

Biological Resource Center, National Institute of Technology and Evaluation (NBRC), 2-49-10 Nishihara, Shibuya-ku, Tokyo 151-0006, Japan.

出版信息

Nucleic Acids Res. 2013 Jan;41(Database issue):D408-14. doi: 10.1093/nar/gks1177. Epub 2012 Nov 26.

DOI:10.1093/nar/gks1177
PMID:23185043
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3531092/
Abstract

This article introduces DoBISCUIT (Database of BIoSynthesis clusters CUrated and InTegrated, http://www.bio.nite.go.jp/pks/), a literature-based, manually curated database of gene clusters for secondary metabolite biosynthesis. Bacterial secondary metabolites often show pharmacologically important activities and can serve as lead compounds and/or candidates for drug development. Biosynthesis of each secondary metabolite is catalyzed by a number of enzymes, usually encoded by a gene cluster. Although many scientific papers describe such gene clusters, the gene information is not always described in a comprehensive manner and the related information is rarely integrated. DoBISCUIT integrates the latest literature information and provides standardized gene/module/domain descriptions related to the gene clusters.

摘要

本文介绍了 DoBISCUIT（生物合成簇数据库的编目和整合，http://www.bio.nite.go.jp/pks/），这是一个基于文献的、人工编目的细菌次生代谢产物生物合成基因簇数据库。细菌次生代谢产物通常具有重要的药理活性，可以作为先导化合物和/或药物开发的候选物。每种次生代谢产物的生物合成都由一系列酶催化，这些酶通常由一个基因簇编码。尽管许多科学论文都描述了这些基因簇，但基因信息并不总是全面描述的，相关信息也很少整合。DoBISCUIT 整合了最新的文献信息，并提供了与基因簇相关的标准化基因/模块/结构域描述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f0/3531092/11a916670377/gks1177f3p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f0/3531092/d7cd4695e38b/gks1177f1p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f0/3531092/48d451f5cd6f/gks1177f2p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f0/3531092/11a916670377/gks1177f3p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f0/3531092/d7cd4695e38b/gks1177f1p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f0/3531092/48d451f5cd6f/gks1177f2p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96f0/3531092/11a916670377/gks1177f3p.jpg

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