Department of Obstetrics & Gynaecology, Anu Research Centre, University College Cork, Cork, Ireland.
Br J Pharmacol. 2013 Mar;168(5):1074-85. doi: 10.1111/bph.12069.
Peroxisome proliferator activated receptors (PPARs) are ligand-activated transcription factors expressed in trophoblasts, which regulate both cell differentiation and proliferation. In recent years, evidence has linked PPARs to playing an integral role in pregnancy; specifically, PPAR-β and PPAR-γ have been shown to play an integral role in placentation, with PPAR-γ additionally serving to regulate trophoblast differentiation. Recent evidence has shown that PPAR-γ expression is altered in many complications of pregnancy such as intrauterine growth restriction (IUGR), preterm birth, pre-clampsia and gestational diabetes. Thus, at present, accumulating evidence from the literature suggests both a pivotal role for PPAR-γ in the progression of a healthy pregnancy and the possibility that PPAR-γ may act as a therapeutic target in complicated pregnancies. This review aims to provide a succinct and comprehensive assessment of the role of PPAR-γ in normal pregnancy and pregnancy complications, and finally its potential as a therapeutic target in the treatment and/or prevention of adverse pregnancy outcomes.
过氧化物酶体增殖物激活受体 (PPARs) 是在滋养层细胞中表达的配体激活转录因子，可调节细胞分化和增殖。近年来，有证据表明 PPARs 在妊娠中起着重要作用；具体来说，已经证明 PPAR-β 和 PPAR-γ 在胎盘形成中起着重要作用，而 PPAR-γ 还可以调节滋养层细胞的分化。最近的证据表明，许多妊娠并发症如宫内生长受限 (IUGR)、早产、先兆子痫和妊娠期糖尿病中 PPAR-γ 的表达发生了改变。因此，目前，文献中的累积证据表明 PPAR-γ 在健康妊娠的进展中起着关键作用，并且 PPAR-γ 可能成为复杂妊娠的治疗靶点。本综述旨在对 PPAR-γ 在正常妊娠和妊娠并发症中的作用进行简明而全面的评估，并最终探讨其作为治疗和/或预防不良妊娠结局的治疗靶点的潜力。
