单电子转移诱导的涉及离子自由基作为唯一中间体的 Grignard 交叉偶联。

Single electron transfer-induced Grignard cross-coupling involving ion radicals as exclusive intermediates.

机构信息

Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto, 606-8502, Japan.

出版信息

Chem Commun (Camb). 2013 Jan 14;49(4):364-6. doi: 10.1039/c2cc37643a. Epub 2012 Nov 27.

Abstract

The mechanism of the previously developed cross-coupling reaction of aryl Grignard reagents with aryl halides was explored in more detail. Single electron transfer from an aryl Grignard reagent to an aryl halide initiates a radical chain by giving an anion radical of the aryl halide. The following propagation cycle consists entirely of anion radical intermediates.

摘要

先前开发的芳基格氏试剂与芳基卤化物的交叉偶联反应的机理被更详细地探讨。芳基格氏试剂向芳基卤化物单电子转移通过生成芳基卤化物的阴离子自由基引发自由基链。随后的扩展循环完全由阴离子自由基中间体组成。