Phung Thuy L, Hochman Marcelo
Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA.
Facial Plast Surg. 2012 Dec;28(6):554-62. doi: 10.1055/s-0032-1329930. Epub 2012 Nov 27.
Cutaneous vascular anomalies are congenital disorders of abnormal vascular development and growth. Infantile hemangioma is a common type of vascular anomalies characterized by the abnormal growth of blood vessels in the early proliferative phase, followed by the gradual spontaneous regression of the lesion in the involuting phase. Over the past decade, significant advances have been made in our understanding of the cellular and molecular mechanisms that control the development, growth, and regression of infantile hemangioma. In this article, we present a comprehensive review of the current knowledge of the pathogenesis of hemangioma as well as promising research horizons and implications for new therapeutic advances.
皮肤血管异常是血管发育和生长异常的先天性疾病。婴儿血管瘤是一种常见的血管异常类型，其特征是在早期增殖阶段血管异常生长，随后在消退阶段病变逐渐自发消退。在过去十年中，我们对控制婴儿血管瘤发生、生长和消退的细胞和分子机制的理解取得了重大进展。在本文中，我们对血管瘤发病机制的当前知识以及有前景的研究方向和新治疗进展的意义进行了全面综述。
