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婴儿血管瘤的管理:最新进展

Management of infantile hemangiomas: Recent advances.

作者信息

Xu Wei, Zhao Haiguang

机构信息

Department of Plastic Surgery, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, Shandong, China.

出版信息

Front Oncol. 2022 Nov 29;12:1064048. doi: 10.3389/fonc.2022.1064048. eCollection 2022.

DOI:10.3389/fonc.2022.1064048
PMID:36523969
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9745076/
Abstract

Infantile hemangiomas (IHs) are benign vascular tumors commonly observed in children. A small number of cases can manifest as organ or system dysfunction, permanent scarring, or even disfigurement. Currently, diagnosis is mainly based on clinical history, physical examination, and auxiliary inspection. In the treatment of a hemangioma, the functional damage caused by the lesion and complications that may endanger the patient's life should be given priority. This suggests that identification, diagnosis, and referral to specialists during the early stages of IHs are important factors in preventing related complications and obtaining a better prognosis. During the past few decades, researchers have explored different treatments according to the condition, including oral or topical drugs, topical drug injections, laser surgery, and surgical treatment. However, oral propranolol remains a well-accepted first-line treatment. This article will primarily focus on the recent advances in the clinical diagnosis and treatment of hemangiomas, along with a literature review on the subject.

摘要

婴儿血管瘤(IHs)是儿童常见的良性血管肿瘤。少数病例可表现为器官或系统功能障碍、永久性瘢痕,甚至毁容。目前,诊断主要基于临床病史、体格检查和辅助检查。在血管瘤的治疗中,应优先考虑病变引起的功能损害以及可能危及患者生命的并发症。这表明在婴儿血管瘤的早期阶段进行识别、诊断并转诊至专科医生是预防相关并发症并获得更好预后的重要因素。在过去几十年中,研究人员根据病情探索了不同的治疗方法,包括口服或外用药物、局部药物注射、激光手术和手术治疗。然而,口服普萘洛尔仍然是广泛接受的一线治疗方法。本文将主要关注血管瘤临床诊断和治疗的最新进展,并对该主题进行文献综述。

相似文献

1
Management of infantile hemangiomas: Recent advances.婴儿血管瘤的管理:最新进展
Front Oncol. 2022 Nov 29;12:1064048. doi: 10.3389/fonc.2022.1064048. eCollection 2022.
2
Infantile Hemangioma: An Updated Review.婴儿血管瘤:最新综述
Curr Pediatr Rev. 2021;17(1):55-69. doi: 10.2174/1573396316666200508100038.
3
Update on Treatment of Infantile Hemangiomas: What's New in the Last Five Years?婴儿血管瘤治疗的最新进展:过去五年有哪些新变化?
Front Pharmacol. 2022 May 26;13:879602. doi: 10.3389/fphar.2022.879602. eCollection 2022.
4
Infantile Hemangiomas in the Head and Neck Region.头颈部的婴儿血管瘤
Otolaryngol Clin North Am. 2018 Feb;51(1):77-87. doi: 10.1016/j.otc.2017.09.009.
5
Infantile Hemangiomas: A Review of Current Treatment Options.婴幼儿血管瘤:当前治疗选择的综述。
Pediatr Ann. 2023 May;52(5):e192-e197. doi: 10.3928/19382359-20230307-02. Epub 2023 May 1.
6
Clinical and economic impact of surgery for treating infantile hemangiomas in the era of propranolol: overview of single-center experience from La Paz Hospital, Madrid.普萘洛尔时代治疗婴幼儿血管瘤手术的临床和经济影响:马德里拉帕兹医院单中心经验概述。
Eur J Pediatr. 2019 Jan;178(1):1-6. doi: 10.1007/s00431-018-3290-z. Epub 2018 Nov 12.
7
Clinical Practice Guideline for the Management of Infantile Hemangiomas.婴幼儿血管瘤管理临床实践指南。
Pediatrics. 2019 Jan;143(1). doi: 10.1542/peds.2018-3475.
8
Topical Timolol Vs. Oral Propranolol for the Treatment of Superficial Infantile Hemangiomas.局部用噻吗洛尔与口服普萘洛尔治疗浅表性婴儿血管瘤的对比研究
Front Oncol. 2018 Dec 18;8:605. doi: 10.3389/fonc.2018.00605. eCollection 2018.
9
Safe and Effective Treatment of Intracranial Infantile Hemangiomas with Beta-Blockers.β受体阻滞剂安全有效地治疗颅内婴儿血管瘤
Pediatr Rep. 2021 Jul 1;13(3):347-356. doi: 10.3390/pediatric13030043.
10
Propranolol therapy for infantile hemangioma: our experience.普萘洛尔治疗婴儿血管瘤:我们的经验。
Drug Des Devel Ther. 2017 May 8;11:1401-1408. doi: 10.2147/DDDT.S134808. eCollection 2017.

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Lower li1mb mesenchymal hamartoma masquerading as hemangioma: a case report of AA2 atypical presentation and diagnostic challenges.伪装成血管瘤的下肢间叶性错构瘤:AA2非典型表现及诊断挑战的病例报告
Ann Med Surg (Lond). 2024 Jul 1;86(9):5518-5522. doi: 10.1097/MS9.0000000000002339. eCollection 2024 Sep.
2
The Role of Natural Extracts in the Management of Infantile Hemangiomas and Vascular Tumors.天然提取物在婴儿血管瘤和血管肿瘤治疗中的作用
Pediatric Health Med Ther. 2024 Jan 6;15:1-16. doi: 10.2147/PHMT.S439537. eCollection 2024.
3
Effects of follicle-stimulating hormone on the proliferation and apoptosis of infantile hemangioma stem cells.促卵泡生成素对婴儿血管瘤干细胞增殖和凋亡的影响。
Biochem Biophys Rep. 2023 Sep 30;35:101551. doi: 10.1016/j.bbrep.2023.101551. eCollection 2023 Sep.
4
Hepatic hemangiomas with arterioportal shunt complicated a congestive heart failure: a case report.肝血管瘤伴动静脉分流引起充血性心力衰竭:一例报告。
Pan Afr Med J. 2023 Apr 18;44:181. doi: 10.11604/pamj.2023.44.181.39820. eCollection 2023.
5
Genetic Polymorphisms of Vascular Endothelial Growth Factor in Neonatal Pathologies: A Systematic Search and Narrative Synthesis of the Literature.新生儿疾病中血管内皮生长因子的基因多态性:文献的系统检索与叙述性综述
Children (Basel). 2023 Apr 19;10(4):744. doi: 10.3390/children10040744.

本文引用的文献

1
Comparison of the efficacy and safety of lasers, topical timolol, and combination therapy for the treatment of infantile hemangioma: A meta-analysis of 10 studies.比较激光、局部噻吗洛尔和联合治疗婴幼儿血管瘤的疗效和安全性:10 项研究的荟萃分析。
Dermatol Ther. 2022 Dec;35(12):e15907. doi: 10.1111/dth.15907. Epub 2022 Nov 9.
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Infantile haemangiomas.婴儿血管瘤
BMJ. 2022 Jul 6;378:e068734. doi: 10.1136/bmj-2021-068734.
3
Incidence and familial clustering of infantile haemangiomas: a multicentre study.婴儿血管瘤的发病率和家族聚集性:一项多中心研究。
J Eur Acad Dermatol Venereol. 2022 Sep;36(9):1641-1647. doi: 10.1111/jdv.18179. Epub 2022 May 9.
4
Infantile Hemangioma: A Current Review.婴儿血管瘤:当前综述
J Pediatr Hematol Oncol. 2022 Mar 1;44(2):31-39. doi: 10.1097/MPH.0000000000002384.
5
Significance of the pulsed dye laser in treatment of acral infantile hemangioma.脉冲染料激光在治疗婴幼儿肢端血管瘤中的意义
J Dtsch Dermatol Ges. 2022 Jan;20(1):97-101. doi: 10.1111/ddg.14635. Epub 2021 Dec 1.
6
Noninferiority and Safety of Nadolol vs Propranolol in Infants With Infantile Hemangioma: A Randomized Clinical Trial.纳多洛尔与普萘洛尔治疗婴儿血管瘤的非劣效性和安全性:一项随机临床试验。
JAMA Pediatr. 2022 Jan 1;176(1):34-41. doi: 10.1001/jamapediatrics.2021.4565.
7
Infantile Hemangiomas: An Update on Pathogenesis and Treatment.婴儿血管瘤:发病机制与治疗的最新进展
J Clin Med. 2021 Oct 9;10(20):4631. doi: 10.3390/jcm10204631.
8
Vascular endothelial growth factor response with propranolol therapy in patients with infantile hemangioma.普萘洛尔治疗婴幼儿血管瘤患者的血管内皮生长因子反应。
Pediatr Hematol Oncol. 2022 Apr;39(3):215-224. doi: 10.1080/08880018.2021.1961956. Epub 2021 Sep 3.
9
Infantile hemangioma. Part 2: Management.婴儿血管瘤。第2部分:管理
J Am Acad Dermatol. 2021 Dec;85(6):1395-1404. doi: 10.1016/j.jaad.2021.08.020. Epub 2021 Aug 19.
10
Infantile Hemangiomas Cleared by Combined Therapy With Pulsed Dye Laser and Propranolol.脉冲染料激光联合普萘洛尔治疗清除婴儿血管瘤
Dermatol Surg. 2021 Aug 1;47(8):1052-1057. doi: 10.1097/DSS.0000000000003018.