Veltri K L, Espiritu M, Singh G
Ontario Cancer Foundation, Hamilton, Canada.
J Cell Physiol. 1990 Apr;143(1):160-4. doi: 10.1002/jcp.1041430122.
This study shows that mitochondria in liver, kidney, heart, and brain of the mouse have a distinct mitochondrial density. It also demonstrates that the mtDNA copy number per mitochondrion is organ-specific. A reliable method of determining mitochondrial density per organ is by stereological analysis of tissue sections while mtDNA quantitation is by the use of radiolabelled mtDNA probe. This is the first study in which a comprehensive examination of mitochondrial density and quantitation of mitochondrial genomes in mouse organs have been done. In summary the variability is not only in mitochondrial density but also in genomic copy number in mitochondria of various tissues.
这项研究表明，小鼠肝脏、肾脏、心脏和大脑中的线粒体具有独特的线粒体密度。研究还表明，每个线粒体的mtDNA拷贝数具有器官特异性。确定每个器官线粒体密度的可靠方法是对组织切片进行体视学分析，而mtDNA定量则是使用放射性标记的mtDNA探针。这是第一项对小鼠器官中线粒体密度和线粒体基因组定量进行全面检查的研究。总之，差异不仅存在于线粒体密度，还存在于各种组织线粒体的基因组拷贝数中。
