Badimon J J, Badimon L, Fuster V
Division of Cardiology, Mount Sinai Medical School of Medicine, New York 10029.
J Clin Invest. 1990 Apr;85(4):1234-41. doi: 10.1172/JCI114558.
The effects of homologous plasma HDL and VHDL fractions on established atherosclerotic lesions were studied in cholesterol-fed rabbits. Atherosclerosis was induced by feeding the animals a 0.5% cholesterol-rich diet for 60 d (group 1). Another group of animals were maintained on the same diet for 90 d (group 2). A third group was also fed the same diet for 90 d but received 50 mg HDL-VHDL protein per wk (isolated from normolipemic rabbit plasma) during the last 30 d (group 3). Aortic atherosclerotic involvement at the completion of the study was 34 +/- 4% in group 1, 38.8 +/- 5% in group 2, and 17.8 +/- 4% in group 3 (P less than 0.005). Aortic lipid deposition was also significantly reduced in group 3 compared with group 1 (studied at only 60 d) and group 2. This is the first in vivo, prospective evidence of the antiatherogenic effect of HDL-VHDL against preexisting atherosclerosis. Our results showed that HDL plasma fractions were able to induce regression of established aortic fatty streaks and lipid deposits. Our results suggest that it may be possible not only to inhibit progression but even to reduce established atherosclerotic lesions by HDL administration.
在喂食胆固醇的兔子身上研究了同源血浆高密度脂蛋白（HDL）和极高密度脂蛋白（VHDL）组分对已形成的动脉粥样硬化病变的影响。通过给动物喂食含0.5%胆固醇的饮食60天来诱导动脉粥样硬化（第1组）。另一组动物维持相同饮食90天（第2组）。第三组也喂食相同饮食90天，但在最后30天每周接受50毫克HDL-VHDL蛋白（从血脂正常的兔血浆中分离）（第3组）。研究结束时，第1组主动脉粥样硬化累及率为34±4%，第2组为38.8±5%，第3组为17.8±4%（P<0.005）。与第1组（仅在60天时研究）和第2组相比，第3组主动脉脂质沉积也显著减少。这是HDL-VHDL对已存在的动脉粥样硬化具有抗动脉粥样硬化作用的首个体内前瞻性证据。我们的结果表明，HDL血浆组分能够诱导已形成的主动脉脂肪条纹和脂质沉积消退。我们的结果表明，通过给予HDL，不仅有可能抑制动脉粥样硬化的进展，甚至有可能减少已形成的动脉粥样硬化病变。
