Pharmaceutical and Medicinal Chemistry Department, The Pharmacetical and Drug Industries Research Division, National Research Centre, Dokki, Cairo 12311, Egypt.
Mini Rev Med Chem. 2013 Mar;13(3):385-98. doi: 10.2174/1389557511313030007.
Much work has been carried out in the last two decades on the role of oxidative stress and antioxidants deficiency in the pathophysiology of civilization diseases. A considerable amount of chemical, biochemical, epidemiological and clinical evidence indicates that (poly)phenolic compounds widely distributed in the plant kingdom, exhibit a wide range effects on biomolecules. The beneficial effects on human health, many of phenolics have been described to their reactive oxygen (ROS) and nitrogen species (RNS) scavenging and antioxidant capacity. The consumption of vegetables, fruits and flavonoid-rich beverages has been reported to prevent against neurodegenerative diseases, cancer, and ageing. This paper reviews the recent data on (1) the role oxidative stress in the pathology of civilization diseases; (2) the protection against oxidative damage due to the toxicity of ROS/RNS; (3) the cellular and molecular interactions of the (poly)phenolic compounds relevant to the prevention of neurodegenerative diseases and cancer, and (4) the methods for assessing antioxidant capacity.
在过去的二十年里，人们对氧化应激和抗氧化剂缺乏在文明病发病机制中的作用进行了大量的研究。大量的化学、生化、流行病学和临床证据表明，广泛分布在植物界的（多）酚类化合物对生物分子表现出广泛的作用。许多酚类化合物因其对活性氧（ROS）和活性氮物种（RNS）的清除作用和抗氧化能力而对人类健康有益。蔬菜、水果和富含类黄酮的饮料的消费被报道可以预防神经退行性疾病、癌症和衰老。本文综述了（1）氧化应激在文明病发病机制中的作用；（2）由于 ROS/RNS 的毒性而对氧化损伤的保护；（3）与预防神经退行性疾病和癌症相关的（多）酚类化合物的细胞和分子相互作用；（4）评估抗氧化能力的方法。
