转铁蛋白包覆的纳米粒/质粒 DNA/分支型聚乙烯亚胺复合物增强脑胶质瘤细胞摄取和基因转染。
Enhanced cellular uptake and gene delivery of glioblastoma with deferoxamine-coated nanoparticle/plasmid DNA/branched polyethylenimine composites.
机构信息
Institute of Creativity and Department of Chemistry, The Hong Kong Baptist University, Kowloon, Hong Kong SAR, P. R. China.
出版信息
Chem Commun (Camb). 2013 Jan 21;49(6):549-51. doi: 10.1039/c2cc36663k. Epub 2012 Nov 28.
PMID:23192002
Abstract
Ternary composite nanomaterials based on deferoxamine-coated superparamagnetic iron oxide nanoparticles (8-10 nm), circular plasmid DNA (~4 kb) with fluorescent/luminescent reporter group, and branched polyethylenimine (25 kDa, PDI = 2.5) were prepared and compared in terms of their efficiencies in transfecting brain tumor cells at low concentration.
摘要
基于去铁胺包覆的超顺磁性氧化铁纳米粒子（8-10nm）、带有荧光/发光报告基团的环状质粒 DNA（~4kb）和支化聚乙烯亚胺（25kDa，PDI=2.5）的三元复合纳米材料，在低浓度下转染脑肿瘤细胞的效率方面进行了比较。
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