Laboratory for Organic & Microwave-Assisted Chemistry, (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, B-3001, Leuven, Belgium.
Chem Soc Rev. 2013 Feb 7;42(3):1121-46. doi: 10.1039/c2cs35397k.
In recent years, reaction of inexpensive and abundantly available alcohols (C-OH) with unactivated nucleophilic coupling partners (C-H), leading to the construction of the C-C bond, has emerged as one of the vital strategies since it is an atom-economical and environmentally benign approach with water as the by-product. Various transition metal-catalyzed or metal-free approaches for the direct dehydrative coupling employing the C-OH bond (including in situ activation) have recently been devised. This review article aims to highlight advances in such waste-free C-C bond forming dehydrative strategies.
近年来，廉价且丰富的醇（C-OH）与非活化亲核偶联试剂（C-H）反应，构建 C-C 键，已成为一种重要策略，因为这是一种原子经济和环境友好的方法，副产物为水。最近已经设计了各种过渡金属催化或无金属的方法，用于直接脱水偶联 C-OH 键（包括原位活化）。本文旨在强调无废物 C-C 键形成脱水策略方面的进展。
