Jiang Yi-Jun, Hu Hao-Lan, Niu Yu-Dan, Li Meng-Yuan, Chen Peng
Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis of Zhejiang Province, Institute of Mass Spectrometry, School of Material Science and Chemical Engineering, Ningbo University, Ningbo, 315211, Zhejiang, People's Republic of China.
Mol Divers. 2025 Aug 20. doi: 10.1007/s11030-025-11286-4.
A simple and efficient iron-catalyzed divergent dehydrative coupling of carbazoles and benzylic alcohols has been developed. By using different iron catalysts, mono-substituted or di-substituted carbazole-based di-/triarylmethanes, some of which are bioactive and potential pharmaceutical molecules or potential molecular precursors for optoelectronic materials, were synthesized site-selectively from the same set of reactants. This method was demonstrated with 68 examples, in up to 98% yield and with broad functional group compatibilities.
已开发出一种简单高效的铁催化咔唑与苄醇的发散性脱水偶联反应。通过使用不同的铁催化剂，从同一组反应物中位点选择性地合成了单取代或二取代的咔唑基二芳基甲烷或三芳基甲烷，其中一些是生物活性和潜在的药物分子或光电子材料的潜在分子前体。该方法通过68个实例得到验证，产率高达98%，且具有广泛的官能团兼容性。
