Hu Zhenjun
Bioinformatics Program, Boston University, Boston, MA, USA.
Methods Mol Biol. 2013;939:141-81. doi: 10.1007/978-1-62703-107-3_11.
Protein interactions, as well as the networks they formed, play a key role in many cellular processes and the distortion of the protein interacting interfaces may lead to the development of many diseases. In this chapter, we will briefly introduce the background knowledge of the protein-protein interaction, followed by the detailed explanation of varied analysis-from basic to advanced, as well as related tools and databases. VisANT (http://visant.bu.edu)-a free Web-based software platform for the integrative visualization, mining, analysis, and modeling of the biological networks-will be used as a main tool for all examples used in this section.
蛋白质相互作用及其形成的网络在许多细胞过程中起着关键作用，蛋白质相互作用界面的扭曲可能导致多种疾病的发生。在本章中，我们将简要介绍蛋白质-蛋白质相互作用的背景知识，随后详细解释从基础到高级的各种分析方法，以及相关工具和数据库。VisANT（http://visant.bu.edu）——一个基于网络的免费软件平台，用于生物网络的综合可视化、挖掘、分析和建模——将作为本节所有示例的主要工具。
