Satten G A, Kupper L L
Department of Biostatistics, School of Public Health, University of North Carolina, Chapel Hill 27599-7400.
J Clin Epidemiol. 1990;43(1):55-9. doi: 10.1016/0895-4356(90)90056-u.
Samples sizes are calculated for case-control studies where 1:1 matching has been employed, and where the goal is the interval estimation of the odds ratio. The optimal sample size is defined to be the smallest value for which a 100(1 - alpha)% confidence interval for the log odds ratio will not exceed a specified width 2 delta with specified probability (1 - gamma). This approach is similar in spirit to the power-based approach for sample size determination when significance testing is the goal. Tables of sample sizes are presented for various choices of parameters. We also find considerable disagreement with a published method based on expected numbers of discordant pairs.
样本量是针对采用1:1匹配且目标是对比值比进行区间估计的病例对照研究计算的。最优样本量被定义为这样一个最小值，即对于该值，对数比值比的100(1 - α)%置信区间在指定概率(1 - γ)下不会超过指定宽度2δ。这种方法在本质上类似于以显著性检验为目标时基于功效的样本量确定方法。文中给出了针对各种参数选择的样本量表格。我们还发现与一种基于不一致对预期数量的已发表方法存在很大分歧。
