Guntheroth W G, Lohmann R, Spiers P S
Department of Pediatrics, University of Washington School of Medicine, Seattle.
J Pediatr. 1990 Apr;116(4):520-4. doi: 10.1016/s0022-3476(05)81596-3.
To determine the risk of recurrence of sudden infant death syndrome in families, we studied 251,124 live births by linked birth and death certificates from Oregon for a 10-year period. We found five recurrences among 385 subsequent siblings, for a rate of 13/1000 live births and a relative risk of 6. When the recurrences were adjusted separately for birth order and maternal age, the risk was still five times that expected (p less than 0.001). Families with infant deaths from causes other than sudden infant death syndrome had similar recurrence rates, suggesting that the phenomenon was not specific to sudden infant death syndrome. The overall mortality rate for subsequent siblings after a sudden death event totaled 20.8/1000. We believe that a risk of 2%, although small in the design of studies of infants at risk for sudden infant death syndrome, is not trivial in the counseling of parents.
为了确定家庭中婴儿猝死综合征复发的风险，我们通过俄勒冈州10年期间的出生与死亡证明关联研究了251,124例活产儿。我们在385名后续兄弟姐妹中发现了5例复发，复发率为13/1000活产儿，相对风险为6。当分别根据出生顺序和母亲年龄对复发情况进行调整后，风险仍为预期的五倍（p小于0.001）。因婴儿猝死综合征以外原因导致婴儿死亡的家庭具有相似的复发率，这表明该现象并非婴儿猝死综合征所特有。猝死事件后后续兄弟姐妹的总死亡率为20.8/1000。我们认为，2%的风险尽管在婴儿猝死综合征风险研究的设计中很小，但在为父母提供咨询时并非微不足道。
