Jadhav Manoj P, Jadhav Priyanka M, Mutke Amol P, Sonawane Supriya D, Patil Bhushan D, Naik Narendra B, Sonawale Archana S
Department of Infectious Diseases, Maharashtra University of Health Sciences. Parel, Mumbai, India.
Indian J Med Sci. 2011 Feb;65(2):58-63.
Osteoarthritis (OA) is a major cause of disability and is focused in "Bone and Joint Decade" declared by WHO which substantially affect different dimensions of quality of life. The aim of present study was to find the disease pattern in OA patients, monitoring prescription pattern to assess prognosis of osteoarthritis by WOMAC index.
An observational study on prospective data collected for the evaluation of Quality of Life (QOL) in OA was conducted at tertiary health care centre in Mumbai. Patients with a diagnosis of OA were enrolled. The patient's history and clinical examination was based on classification criteria of the American College of Rheumatology; drugs prescribed were noted on case record form. Same procedure was carried out for the first and second follow-ups at 6 th and 12 th weeks respectively.
The patients belong to primary OA (84%) as compared to secondary OA (16%). Females (70.56% and 10%) were affected more commonly than males (13.44% and 6%). Knee Joint was worst affected in 76%, followed by hip joint in 16% and shoulder, ankle, wrist, elbow joint each having 2% (n=1) involvement. NSAIDs continued to dominate prescriptions given to 84% of patients followed by antiarthritic drugs and calcium supplements in 54% cases. The WOMAC score was higher in most of patients. After medication hydroxy chloroquine sulfate has shown maximum reduction in average WOMAC sore followed by paracetamol, indomethacin and diclofenac sodium.
Osteoarthritis has a significant impact on quality of life, only partly ameliorated by anti-arthritic drugs, as assessed by the WOMAC scale in this study population. Further, a study with larger sample size is needed to further support our findings.
骨关节炎（OA）是导致残疾的主要原因，是世界卫生组织宣布的“骨与关节十年”关注的重点，它严重影响生活质量的各个方面。本研究的目的是找出OA患者的疾病模式，通过WOMAC指数监测处方模式以评估骨关节炎的预后。
在孟买的三级医疗保健中心对收集的用于评估OA患者生活质量（QOL）的前瞻性数据进行了一项观察性研究。纳入诊断为OA的患者。患者的病史和临床检查基于美国风湿病学会的分类标准；在病例记录表上记录所开药物。分别在第6周和第12周进行第一次和第二次随访时执行相同程序。
与继发性OA（16%）相比，患者多属于原发性OA（84%）。女性（70.56%和10%）比男性（13.44%和6%）更常受影响。76%的患者膝关节受累最严重，其次是髋关节，占16%，而肩关节、踝关节、腕关节、肘关节各有2%（n = 1）受累。非甾体抗炎药继续在84%的患者处方中占主导地位，其次是抗关节炎药物和钙补充剂，占54%的病例。大多数患者的WOMAC评分较高。用药后，硫酸羟氯喹平均WOMAC评分降低最多，其次是对乙酰氨基酚、吲哚美辛和双氯芬酸钠。
在本研究人群中，通过WOMAC量表评估，骨关节炎对生活质量有重大影响，抗关节炎药物仅能部分改善。此外，需要进行更大样本量的研究来进一步支持我们的发现。
