Centro de Investigación en Alimentación y Desarrollo A.C., km 0.6 Carretera a la Victoria, Hermosillo, Sonora, Mexico.
Environ Monit Assess. 2013 Jul;185(7):6111-7. doi: 10.1007/s10661-012-3011-4. Epub 2012 Nov 30.
The aim of this study was to evaluate the presence of total and inorganic arsenic in dietary supplements composed of herbal plants and seaweed, and to determine the potential toxicological risk. Total arsenic was determined by dry ashing and hydride generation atomic absorption spectrometry, and inorganic arsenic was determined by acid digestion, solvent extraction, and hydride generation atomic absorption spectrometry. Total and inorganic arsenic in the supplements ranged from 0.07 to 8.31 mg kg(-1) dry weight and from 0.14 to 0.28 mg kg(-1) dry weight, respectively. Daily intake of total arsenic ranged from 0.05 to 12.46 μg day(-1). Inorganic arsenic intake ranged from 0.21 to 0.83 μg day(-1), values that are below the Benchmark Dose Lower Confidence Limit recommended by the Word Health Organization. Therefore, there appears to be a low risk of adverse effects resulting from excess inorganic arsenic intake from these supplements. This is the first study conducted in Mexico that investigates total and inorganic arsenic in dietary supplements. Although the results do not suggest toxicological risk, it is nonetheless important considering the toxicity of inorganic arsenic and the increasing number consumer preferences for dietary supplements. Moreover, it is important to improve and ensure the safety of dietary supplements containing inorganic arsenic.
本研究旨在评估由草药和海藻组成的膳食补充剂中总砷和无机砷的存在，并确定其潜在的毒理学风险。总砷通过干法灰化和氢化物发生原子吸收光谱法测定，无机砷通过酸消解、溶剂萃取和氢化物发生原子吸收光谱法测定。补充剂中的总砷和无机砷含量范围分别为 0.07 至 8.31mg/kg（干重）和 0.14 至 0.28mg/kg（干重）。总砷的日摄入量范围为 0.05 至 12.46μg/天。无机砷的摄入量范围为 0.21 至 0.83μg/天，这些值低于世界卫生组织推荐的无机砷基准剂量下限置信区间。因此，从这些补充剂中摄入过量无机砷似乎不太可能产生不良影响。这是墨西哥首次进行的膳食补充剂中总砷和无机砷含量的研究。尽管结果并未提示存在毒理学风险，但考虑到无机砷的毒性以及消费者对膳食补充剂的偏好日益增加，这一点仍然很重要。此外，提高和确保含有无机砷的膳食补充剂的安全性非常重要。
