Department of Obstetrics, Gynecology and Reproduction, Institut Universitari Dexeus, Barcelona, Spain.
Stem Cells Transl Med. 2012 Sep;1(9):668-72. doi: 10.5966/sctm.2012-0076. Epub 2012 Sep 7.
Fertility preservation is an emerging field in medicine that enables men, women, and children to maintain reproductive health when it is threatened by gonadotoxic treatment. Patients affected by other nononcologic malignancies that can impair spermatogenesis and ovogenesis can also benefit from fertility preservation treatments. Age-related infertility can also be overcome by cryopreserving gametes or embryos. The only established methods for fertility preservation in male patients are sperm cryopreservation in postpubertal age and experimental testicular tissue cryopreservation in prepubertal age. In adult women, oocyte cryopreservation is the preferred option, whereas ovarian tissue cryopreservation is the only possibility for prepubertal girls. Fertility preservation treatments must be addressed through a multidisciplinary approach that involves gynecologists, urologists, oncologists, pediatricians, and professionals in the field of medically assisted reproduction to work in coordination to provide patients with counseling and comprehensive information about fertility issues.
生育力保存是医学领域的一个新兴领域,使男性、女性和儿童能够在性腺毒性治疗威胁生殖健康时保持生殖健康。其他非肿瘤性恶性肿瘤也会影响精子发生和卵子发生的患者也可以从生育力保存治疗中受益。年龄相关的不孕也可以通过冷冻保存配子或胚胎来克服。在男性患者中,唯一已确立的生育力保存方法是青春期后精子冷冻保存和青春期前实验性睾丸组织冷冻保存。在成年女性中,卵母细胞冷冻保存是首选方法,而卵巢组织冷冻保存是青春期前女孩的唯一选择。生育力保存治疗必须通过多学科方法来解决,涉及妇科医生、泌尿科医生、肿瘤学家、儿科医生和辅助生殖领域的专业人员,以协调工作,为患者提供生育问题的咨询和全面信息。