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经辐照和缩醛化处理的聚乙烯醇水凝胶用于修复骨软骨缺损：大鼠膝关节植入后的力学、化学和组织学评估

Polyvinyl alcohol hydrogel irradiated and acetalized for osteochondral defect repair: mechanical, chemical, and histological evaluation after implantation in rat knees.

作者信息

Batista N A, Rodrigues A A, Bavaresco V P, Mariolani J R L, Belangero W D

机构信息

Orthopaedic Biomaterials Laboratory, Faculty of Medical Sciences, University of Campinas (UNICAMP), Rua Tessália Vieira de Camargo, no. 126, Cidade Universitária "Zeferino Vaz", 13083-887 Campinas, SP, Brazil.

出版信息

Int J Biomater. 2012;2012:582685. doi: 10.1155/2012/582685. Epub 2012 Nov 1.

DOI:10.1155/2012/582685
PMID:23197982
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3503318/
Abstract

Polyvinyl Alcohol (PVA) hydrogel plugs were implanted in artificial osteochondral defects on the trochlear groove of rat knees. After 0, 3, 6, 12, and 24 weeks of followup, samples containing the implants were mechanically evaluated by creep indentation test, chemically, and histologically by optical microscopy. The mechanical test pointed towards an increase of the implant creep modulus and the chemical analysis exhibited an increasing concentration of calcium and phosphorus within the implants over time. Optical microscopy showed no foreign body reaction and revealed formation, differentiation, and maintenance of new tissue at the defect/implant interface. The absence of implant wear indicated that the natural articular lubrication process was not disturbed by the implant. The performance of the irradiated and acetalized PVA was considered satisfactory for the proposed application.

摘要

将聚乙烯醇（PVA）水凝胶塞植入大鼠膝关节滑车沟的人工骨软骨缺损处。在随访0、3、6、12和24周后，通过蠕变压痕试验对含有植入物的样本进行力学评估，并通过光学显微镜进行化学和组织学评估。力学测试表明植入物的蠕变模量增加，化学分析显示植入物中钙和磷的浓度随时间增加。光学显微镜检查未发现异物反应，并显示在缺损/植入物界面有新组织的形成、分化和维持。植入物无磨损表明天然关节润滑过程未受植入物干扰。对于所提出的应用，辐照和缩醛化PVA的性能被认为是令人满意的。

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