Kikuchi Shogo
Department of Public Health, Aichi Medical University, School of Medicine.
Nihon Rinsho. 2012 Oct;70(10):1673-8.
H. pylori infection mainly occurs under five years of age, interruption of which may be an effective preventive strategy against gastric cancer. Infection to children can be interrupted if H. pylori harbored by persons around the children was eradicated. Prevention of gastric cancer death of adults with H. pylori infection may be another strategy. Risk evaluation of gastric cancer for each subject is inevitable because current Japanese population is a mixture of infected high risk subjects and low risk ones. Combined use of serum pepsinogens and H. pylori antibody test is a useful method of the risk evaluation. According to the evaluation, some subjects should undergo H. pylori eradication therapy and/or periodical examination, which may prevent gastric cancer deaths effectively.
幽门螺杆菌感染主要发生在五岁以下，阻断这种感染可能是预防胃癌的有效策略。如果根除儿童周围人群携带的幽门螺杆菌，就可以阻断对儿童的感染。对感染幽门螺杆菌的成年人预防胃癌死亡可能是另一种策略。由于目前的日本人群是感染高危人群和低危人群的混合体，对每个个体进行胃癌风险评估是不可避免的。联合使用血清胃蛋白酶原和幽门螺杆菌抗体检测是一种有用的风险评估方法。根据评估结果，一些受试者应接受幽门螺杆菌根除治疗和/或定期检查，这可能有效地预防胃癌死亡。
