Graham D Y, Kimura K, Shimoyama T, Takemoto T
Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Eur J Gastroenterol Hepatol. 1994 Dec;6 Suppl 1:S1-4.
The combination of the high prevalence of Helicobacter pylori infection in Japan and the availability of methods to diagnose and treat the infection suggest that elimination of the infection from the population might be beneficial. Therefore we reviewed the epidemiology, consequences and possible benefits of elimination of H. pylori in Japan.
H. pylori infection has been etiologically linked to peptic ulcer disease, gastric carcinoma and gastric B-cell lymphoma. The cumulative risk of those with H. pylori infection for developing peptic ulcer disease is 15-20%, with 0.01-0.1% developing gastric carcinoma. Twenty to thirty per cent of those infected suffer mortality or morbidity related to H. pylori infection. Recommendations were made concerning the elimination of this infection.
Eradication of H. pylori should largely eliminate peptic ulcer disease with all its costs and complications, while rapidly changing the risk of developing gastric cancer.
日本幽门螺杆菌感染的高流行率以及诊断和治疗该感染方法的可得性表明，从人群中消除该感染可能有益。因此，我们回顾了日本幽门螺杆菌消除的流行病学、后果及可能的益处。
幽门螺杆菌感染在病因上与消化性溃疡病、胃癌和胃B细胞淋巴瘤相关。幽门螺杆菌感染者发生消化性溃疡病的累积风险为15% - 20%，发生胃癌的风险为0.01% - 0.1%。20%至30%的感染者会出现与幽门螺杆菌感染相关的死亡或发病情况。针对消除这种感染提出了建议。
根除幽门螺杆菌应能在很大程度上消除消化性溃疡病及其所有成本和并发症，同时迅速改变患胃癌的风险。
