• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

糖尿病中的血管内皮功能障碍：循环标志物作为先进诊断和预后工具的潜在应用。

Endothelial dysfunction in diabetes: potential application of circulating markers as advanced diagnostic and prognostic tools.

机构信息

Department of Oral Biology, CL 2140, School of Dentistry, Medical College of Georgia, Augusta, GA 30912-1128 USA.

出版信息

EPMA J. 2010 Mar;1(1):32-45. doi: 10.1007/s13167-010-0012-7. Epub 2010 Mar 10.

DOI:10.1007/s13167-010-0012-7
PMID:23199039
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3405304/
Abstract

Endothelial dysfunction is a predisposing factor for vascular disease in diabetes, which contributes significantly to the mortality of diabetic patients. The currently utilized assessment methods of endothelial function/dysfunction in humans are associated with various limitations. Circulating endothelial-derived/associated markers have been proposed as potential alternatives for evaluation of the endothelium in condition of vascular disorders. These indicators include von Willebrand factor, soluble thrombomodulin, soluble E-selectin, asymmetric dimethylarginine, tissue plasminogen activator, endothelial microparticles, circulating endothelial cells and circulating endothelial progenitor cells. While tentative evidence is available for most of these biomarkers to serve as reliable sources of information, their usefulness for routine clinical applications has not yet been established. Thus, circulating endothelial markers are currently the subject of intense research interest and it is anticipated that as more information becomes available their improved quantification will provide a suitable diagnostic and prognostic tool for vascular events in diabetes and related diseases.

摘要

内皮功能障碍是糖尿病血管疾病的一个致病因素，这极大地导致了糖尿病患者的死亡率。目前用于评估人类内皮功能/障碍的方法存在各种局限性。循环内皮衍生/相关标志物已被提议作为血管疾病情况下评估内皮的潜在替代方法。这些指标包括血管性血友病因子、可溶性血栓调节蛋白、可溶性 E-选择素、不对称二甲基精氨酸、组织型纤溶酶原激活物、内皮微颗粒、循环内皮细胞和循环内皮祖细胞。虽然大多数这些生物标志物都有初步的证据可以作为可靠的信息来源，但它们在常规临床应用中的有用性尚未得到证实。因此，循环内皮标志物目前是研究的热点，随着更多信息的出现，它们的定量检测将为糖尿病和相关疾病的血管事件提供一种合适的诊断和预后工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dac/3405304/ff89ecd3c41f/13167_2010_12_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dac/3405304/d5153771bcac/13167_2010_12_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dac/3405304/61f520ce4837/13167_2010_12_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dac/3405304/afc60b9f4656/13167_2010_12_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dac/3405304/8efbd27534af/13167_2010_12_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dac/3405304/4206a5111ecd/13167_2010_12_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dac/3405304/6cbe063965c1/13167_2010_12_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dac/3405304/ff89ecd3c41f/13167_2010_12_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dac/3405304/d5153771bcac/13167_2010_12_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dac/3405304/61f520ce4837/13167_2010_12_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dac/3405304/afc60b9f4656/13167_2010_12_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dac/3405304/8efbd27534af/13167_2010_12_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dac/3405304/4206a5111ecd/13167_2010_12_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dac/3405304/6cbe063965c1/13167_2010_12_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dac/3405304/ff89ecd3c41f/13167_2010_12_Fig7_HTML.jpg

相似文献

1
Endothelial dysfunction in diabetes: potential application of circulating markers as advanced diagnostic and prognostic tools.糖尿病中的血管内皮功能障碍：循环标志物作为先进诊断和预后工具的潜在应用。
EPMA J. 2010 Mar;1(1):32-45. doi: 10.1007/s13167-010-0012-7. Epub 2010 Mar 10.
2
Endothelial (dys)function in lone atrial fibrillation.孤立性心房颤动中的内皮（功能障碍）功能
Curr Pharm Des. 2015;21(5):622-45. doi: 10.2174/1381612820666140825143028.
3
Biochemical and biophysical markers of endothelial dysfunction in adults with hypopituitarism and severe GH deficiency.垂体功能减退和严重生长激素缺乏的成年人内皮功能障碍的生化和生物物理标志物。
J Clin Endocrinol Metab. 2001 Sep;86(9):4223-32. doi: 10.1210/jcem.86.9.7813.
4
Advanced glycation end-product peptides are associated with impaired renal function, but not with biochemical markers of endothelial dysfunction and inflammation, in non-diabetic individuals.在非糖尿病个体中，晚期糖基化终产物肽与肾功能受损相关，但与内皮功能障碍和炎症的生化标志物无关。
Nephrol Dial Transplant. 2006 Mar;21(3):677-82. doi: 10.1093/ndt/gfi309. Epub 2005 Dec 5.
5
Circulating endothelial cell markers in peripheral vascular disease: relationship to the location and extent of atherosclerotic disease.
Eur J Clin Invest. 1997 Nov;27(11):916-21. doi: 10.1046/j.1365-2362.1997.2180766.x.
6
ACE-inhibition modulates some endothelial functions in healthy subjects and in normotensive type 1 diabetic patients.血管紧张素转换酶抑制可调节健康受试者和血压正常的1型糖尿病患者的某些内皮功能。
Eur J Clin Invest. 2000 Oct;30(10):853-60. doi: 10.1046/j.1365-2362.2000.00721.x.
7
Prognostic value of plasma levels of thrombomodulin and von Willebrand factor in Egyptian children with acute lymphoblastic leukemia.血栓调节蛋白和血管性血友病因子血浆水平在埃及急性淋巴细胞白血病儿童中的预后价值
J Oncol Pharm Pract. 2014 Oct;20(5):356-61. doi: 10.1177/1078155213508439. Epub 2013 Nov 15.
8
[Markers of endothelial dysfunction: pathogenetic role and diagnostic significance.].[内皮功能障碍的标志物：发病机制作用及诊断意义。]
Klin Lab Diagn. 2019;64(1):34-41. doi: 10.18821/0869-2084-2018-63-34-41.
9
[Assessment of endothelial function in autoimmune diseases].[自身免疫性疾病中内皮功能的评估]
Rev Med Interne. 2014 Aug;35(8):512-23. doi: 10.1016/j.revmed.2013.12.010. Epub 2014 Jan 10.
10
Circulating thrombomodulin as a novel endothelial cell marker: comparison of its behavior with von Willebrand factor and tissue-type plasminogen activator.循环血栓调节蛋白作为一种新型内皮细胞标志物：其与血管性血友病因子和组织型纤溶酶原激活物的行为比较
Am J Hematol. 1992 Sep;41(1):32-9. doi: 10.1002/ajh.2830410107.

引用本文的文献

1
Multi-organ single-cell RNA sequencing in mice reveals early hyperglycemia responses that converge on fibroblast dysregulation.多器官单细胞 RNA 测序在小鼠中揭示了早期高血糖反应，这些反应集中在成纤维细胞失调上。
FASEB J. 2024 Feb 15;38(3):e23448. doi: 10.1096/fj.202302003R.
2
Differential effect of ramadan fasting on intercellular adhesion molecule-1 (ICAM-1) in diabetes mellitus and non-diabetes mellitus patients.斋月禁食对糖尿病和非糖尿病患者细胞间黏附分子-1（ICAM-1）的不同影响。
Heliyon. 2023 Jun 29;9(7):e17273. doi: 10.1016/j.heliyon.2023.e17273. eCollection 2023 Jul.
3
New insight of metabolomics in ocular diseases in the context of 3P medicine.

本文引用的文献

1
Diabetes and kidney disease.糖尿病与肾脏疾病。
Nephrol Nurs J. 2009 Sep-Oct;36(5):461.
2
Role of statins in diabetes complications.他汀类药物在糖尿病并发症中的作用。
Curr Diabetes Rev. 2009 Aug;5(3):165-70. doi: 10.2174/157339909788920901.
3
Circulating endothelial cells, microparticles and progenitors: key players towards the definition of vascular competence.循环内皮细胞、微粒和祖细胞：界定血管功能的关键因素。
3P医学背景下代谢组学在眼部疾病中的新见解。
EPMA J. 2023 Feb 17;14(1):53-71. doi: 10.1007/s13167-023-00313-9. eCollection 2023 Mar.
4
Effects of aerobic, resistance, and combined training on endothelial function and arterial stiffness in older adults: study protocol for a systematic review and meta-analysis.有氧运动、抗阻运动和联合训练对老年人内皮功能和动脉僵硬度的影响：系统评价和荟萃分析的研究方案。
Syst Rev. 2022 Aug 13;11(1):171. doi: 10.1186/s13643-022-02036-w.
5
Endothelial injury in COVID-19 and septic patients.COVID-19 和脓毒症患者的内皮损伤。
Microvasc Res. 2022 Mar;140:104303. doi: 10.1016/j.mvr.2021.104303. Epub 2021 Dec 13.
6
Effects of autonomic nervous system activation on endothelial function in response to acute exercise in hypertensive individuals: study protocol for a randomized double-blind study.自主神经系统激活对高血压个体急性运动时内皮功能的影响：一项随机双盲研究的研究方案。
Trials. 2021 Aug 19;22(1):548. doi: 10.1186/s13063-021-05516-x.
7
Endothelial progenitor cells as the target for cardiovascular disease prediction, personalized prevention, and treatments: progressing beyond the state-of-the-art.内皮祖细胞作为心血管疾病预测、个性化预防及治疗的靶点：超越现有技术水平的进展
EPMA J. 2020 Sep 21;11(4):629-643. doi: 10.1007/s13167-020-00223-0. eCollection 2020 Dec.
8
Prognostic value of admission hyperglycaemia in black Africans with acute coronary syndromes: a cross-sectional study.急性冠状动脉综合征的黑种人入院高血糖的预后价值：一项横断面研究。
Cardiovasc J Afr. 2020 Nov-Dec;31(6):319-324. doi: 10.5830/CVJA-2020-028. Epub 2020 Sep 14.
9
A cell permeant phosphopeptide mimetic of Niban inhibits p38 MAPK and restores endothelial function after injury.一种穿透细胞膜的 Niban 磷酸肽模拟物可抑制 p38 MAPK，并在损伤后恢复内皮功能。
FASEB J. 2020 Jul;34(7):9180-9191. doi: 10.1096/fj.201902745R. Epub 2020 May 12.
10
Admission Glucose and In-hospital Mortality after Acute Myocardial Infarction in Patients with or without Diabetes: A Cross-sectional Study.糖尿病患者与非糖尿病患者急性心肌梗死后的入院血糖水平与院内死亡率：一项横断面研究。
Chin Med J (Engl). 2017 Apr 5;130(7):767-775. doi: 10.4103/0366-6999.202733.
J Cell Mol Med. 2009 Mar;13(3):454-71. doi: 10.1111/j.1582-4934.2008.00639.x.
4
eNOS activation by physical forces: from short-term regulation of contraction to chronic remodeling of cardiovascular tissues.物理力激活内皮型一氧化氮合酶：从收缩的短期调节到心血管组织的慢性重塑
Physiol Rev. 2009 Apr;89(2):481-534. doi: 10.1152/physrev.00042.2007.
5
Human umbilical cord-derived endothelial progenitor cells promote growth cytokines-mediated neorevascularization in rat myocardial infarction.人脐带源内皮祖细胞促进生长细胞因子介导的大鼠心肌梗死新生血管形成。
Chin Med J (Engl). 2009 Mar 5;122(5):548-55.
6
Therapeutic potential of plasma membrane-derived microparticles.质膜衍生微粒的治疗潜力。
Pharmacol Rep. 2009 Jan-Feb;61(1):49-57. doi: 10.1016/s1734-1140(09)70006-4.
7
Caspase-8, a double-edged sword for EPC functioning.半胱天冬酶-8，对内皮祖细胞功能而言是把双刃剑。
Arterioscler Thromb Vasc Biol. 2009 Apr;29(4):444-6. doi: 10.1161/ATVBAHA.108.183087.
8
Time-dependent dynamic mobilization of circulating progenitor cells during percutaneous coronary intervention in diabetics.糖尿病患者经皮冠状动脉介入治疗过程中循环祖细胞的时相依赖性动态动员。
Int J Cardiol. 2010 Jul 9;142(2):199-201. doi: 10.1016/j.ijcard.2008.11.198. Epub 2009 Jan 20.
9
Endothelial dysfunction in diabetes: from mechanisms to therapeutic targets.糖尿病中的内皮功能障碍：从机制到治疗靶点
Curr Med Chem. 2009;16(1):94-112. doi: 10.2174/092986709787002853.
10
Impact of age and gender interaction on circulating endothelial progenitor cells in healthy subjects.年龄和性别相互作用对健康受试者循环内皮祖细胞的影响。
Fertil Steril. 2010 Feb;93(3):843-6. doi: 10.1016/j.fertnstert.2008.10.062. Epub 2008 Dec 25.