Proliferative diabetic retinopathy: predictive and preventive measures at hypoxia induced retinal changes.

Retinal vasculature changes in diabetic patients are most common cause of blindness among eye diseases. Numerous studies have explored the role of the agiogenic factors in the progression of diabetic retinopathy (DR). The balance between angiogenic and antiangiogenic factors has a determining role in the DR progression. Current treatment modalities include laser photocoagulation, intravitreal drug application, and pars plana vitrectomy (ppv). These maneuvers are employed with occurrence of advanced retinal changes. New diagnostic approaches can provide better information for the initial retinal changes thereby requiring a new DR classification and treatment guidelines. The results that are expected from Diabetic Retinopathy Clinical Research Network (DRCR) are at the level where prediction and prevention can not be made. Innovative molecular-imaging technology, can pave the way for application of novel clinical approaches. Identification of pathology-specific biomarkers and their application to diagnosis and treatment, support the individualized treatment algorithms.