常见癌症风险与他汀类药物：一项基于人群的中国人群病例对照研究。

Common cancer risk and statins: a population-based case-control study in a Chinese population.

机构信息

Min Sheng General Hospital, Cancer Center, Department of Radiation Therapy, Taipei, 168, Jingguo Road, Taoyuan City, Taoyuan County 330, Taiwan.

出版信息

Expert Opin Drug Saf. 2013 Jan;12(1):19-27. doi: 10.1517/14740338.2013.744392. Epub 2012 Dec 1.

DOI:10.1517/14740338.2013.744392

PMID:23199231

Abstract

OBJECTIVE

To investigate whether the use of statins is associated with common cancer risk.

METHODS

A population-based case-control study was conducted in Taiwan. Cases were defined as all patients who were aged 18 years and older and had received at least two statin prescriptions for use continuously for at least 6 months before a first-time diagnosis of studied cancers between the period of 2000 and 2008. The controls were matched to cases by age, sex, and index date. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated by using the Cox proportional hazards model.

RESULTS

A total of 6841 cases and 27,364 matched controls were analyzed. The adjusted hazard ratio for any statin use and cancer at any site were 0.76 (95% 0.654, 0.891). There were a significant reduced risk of gastric cancer (HR: 0.26, 95% CI: 0.107, 0.588), liver cancer (HR: 0.44, 95% CI: 0.279, 0.723) and uterine cancer (HR: 0.44, 95% CI: 0.279, 0.723) associated with any statins.

CONCLUSION

Overall, the statins suggested a significant reduced risk of the most common cancers in a large Chinese population, particularly in gastric, liver, and uterine cancers.

摘要

目的

研究他汀类药物的使用是否与常见癌症风险相关。

方法

在台湾进行了一项基于人群的病例对照研究。病例定义为所有年龄在 18 岁及以上且在 2000 年至 2008 年期间首次诊断为所研究癌症之前至少连续 6 个月接受至少两次他汀类药物处方的患者。对照组与病例按年龄、性别和索引日期匹配。使用 Cox 比例风险模型估计调整后的危险比（HR）和 95%置信区间（CI）。

结果

共分析了 6841 例病例和 27364 例匹配对照。任何他汀类药物使用与任何部位癌症的调整后 HR 为 0.76（95%CI：0.654，0.891）。使用任何他汀类药物与胃癌（HR：0.26，95%CI：0.107，0.588）、肝癌（HR：0.44，95%CI：0.279，0.723）和子宫癌（HR：0.44，95%CI：0.279，0.723）的风险显著降低相关。