两例接受阿替普酶溶栓治疗的中风患者发生严重低纤维蛋白原血症的特征分析 - Suppr

Characterization of a severe hypofibrinogenemia induced by alteplase in two patients thrombolysed for stroke.

作者信息

Matrat Aurélie, De Mazancourt Philippe, Derex Laurent, Nighoghossian Norbert, Ffrench Patrick, Rousson Robert, Hanss Michel

出版信息

Thromb Res. 2013 Jan;131(1):e45-8. doi: 10.1016/j.thromres.2012.11.009. Epub 2012 Nov 28.

DOI:10.1016/j.thromres.2012.11.009

PMID:23199548

Abstract

摘要

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Characterization of a severe hypofibrinogenemia induced by alteplase in two patients thrombolysed for stroke.两例接受阿替普酶溶栓治疗的中风患者发生严重低纤维蛋白原血症的特征分析

Thromb Res. 2013 Jan;131(1):e45-8. doi: 10.1016/j.thromres.2012.11.009. Epub 2012 Nov 28.

Drop of PT Quick percent value is associated with both symptomatic and asymptomatic intracranial hemorrhage in patients treated with rt-PA for acute ischemic stroke.在接受rt-PA治疗的急性缺血性卒中患者中，凝血酶原时间快速百分比值下降与有症状和无症状颅内出血均相关。

Thromb Res. 2011 Jan;127(1):65-6. doi: 10.1016/j.thromres.2010.04.018.

Rare severe hypofibrinogenemia induced by tissue plasminogen activator in stroke patients: Case report.组织型纤溶酶原激活物诱发脑卒中患者罕见严重低纤维蛋白原血症：病例报告。

Medicine (Baltimore). 2021 Mar 5;100(9):e24978. doi: 10.1097/MD.0000000000024978.

Treating as early as possible with thrombolysis is crucial, but can we do better in the sub-4.5-hour time window?尽早进行溶栓治疗至关重要，但在4.5小时以内的时间窗内我们能否做得更好呢？

Cerebrovasc Dis. 2011;31(3):229. doi: 10.1159/000322555. Epub 2010 Dec 21.

Thrombolysis at 3-4.5 hours after acute ischemic stroke onset--evidence from the Canadian Alteplase for Stroke Effectiveness Study (CASES) registry.急性缺血性脑卒中发病后 3-4.5 小时的溶栓治疗-来自加拿大阿替普酶治疗脑卒中有效性研究（CASES）登记研究的证据。

Cerebrovasc Dis. 2011;31(3):223-8. doi: 10.1159/000321893. Epub 2010 Dec 21.

Thrombolytic therapy for acute ischemic stroke: risks vs benefits.急性缺血性卒中的溶栓治疗：风险与获益

J Fam Pract. 2003 Oct;52(10):757, 761.

Fibrinogen degradation coagulopathy and bleeding complications after stroke thrombolysis.纤维蛋白原降解性凝血病与溶栓后卒中出血并发症。

Neurology. 2013 Mar 26;80(13):1216-24. doi: 10.1212/WNL.0b013e3182897015. Epub 2013 Mar 13.

Risk of thrombolytic therapy for acute ischemic stroke in patients with current malignancy.当前恶性肿瘤患者急性缺血性脑卒中溶栓治疗的风险。

J Stroke Cerebrovasc Dis. 2011 Mar-Apr;20(2):124-30. doi: 10.1016/j.jstrokecerebrovasdis.2009.10.010. Epub 2010 Jul 3.

Thrombolysis with alteplase 4.5-6 hours after acute ischemic stroke.阿替普酶溶栓治疗急性缺血性脑卒中 4.5-6 小时后。

Eur Neurol. 2011;65(3):170-4. doi: 10.1159/000324291. Epub 2011 Mar 3.

Older age does not increase risk of hemorrhagic complications after intravenous and/or intra-arterial thrombolysis for acute stroke.年龄较大并不会增加急性卒中静脉和/或动脉内溶栓后出血并发症的风险。

J Stroke Cerebrovasc Dis. 2008 Sep;17(5):266-72. doi: 10.1016/j.jstrokecerebrovasdis.2008.03.003.

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Increased microvascular permeability and low level of low-density lipoprotein cholesterol predict symptomatic intracerebral hemorrhage in acute ischemic stroke.微血管通透性增加和低水平的低密度脂蛋白胆固醇可预测急性缺血性脑卒中的症状性颅内出血。

Sci Prog. 2020 Apr-Jun;103(2):36850420924153. doi: 10.1177/0036850420924153.

Risk Factors for Early Intracerebral Hemorrhage after Intravenous Thrombolysis with Alteplase.阿替普酶静脉溶栓后早期脑出血的危险因素。

J Atheroscler Thromb. 2020 Nov 1;27(11):1176-1182. doi: 10.5551/jat.49783. Epub 2020 Feb 28.

Early Acute Ischemic Stroke Management for Pharmacists.药剂师的早期急性缺血性卒中管理

Hosp Pharm. 2020 Feb;55(1):12-25. doi: 10.1177/0018578718791504. Epub 2018 Aug 7.

The Risk of Symptomatic Intracranial Hemorrhage after Thrombolysis for Acute Stroke: Current Concepts and Perspectives.急性卒中溶栓治疗后症状性颅内出血的风险：当前概念与观点

Ann Indian Acad Neurol. 2019 Jul-Sep;22(3):336-340. doi: 10.4103/aian.AIAN_323_18.

Therapies for Hemorrhagic Transformation in Acute Ischemic Stroke.急性缺血性卒中出血转化的治疗方法

Curr Treat Options Neurol. 2017 Jan;19(1):1. doi: 10.1007/s11940-017-0438-5.

Guideline for Reversal of Antithrombotics in Intracranial Hemorrhage: A Statement for Healthcare Professionals from the Neurocritical Care Society and Society of Critical Care Medicine.颅内出血中抗栓药物逆转指南：神经重症监护学会和危重症医学会给医疗保健专业人员的声明

Neurocrit Care. 2016 Feb;24(1):6-46. doi: 10.1007/s12028-015-0222-x.

Transient hypofibrinogenemia due to allopurinol.别嘌醇所致短暂性纤维蛋白原血症

Drug Des Devel Ther. 2014 Sep 2;8:1231-3. doi: 10.2147/DDDT.S66868. eCollection 2014.

Symptomatic intracerebral hemorrhage in acute ischemic stroke after thrombolysis with intravenous recombinant tissue plasminogen activator: a review of natural history and treatment.静脉注射重组组织型纤溶酶原激活剂溶栓后急性缺血性卒中的症状性脑出血：自然史与治疗综述

JAMA Neurol. 2014 Sep;71(9):1181-5. doi: 10.1001/jamaneurol.2014.1210.

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Characterization of a severe hypofibrinogenemia induced by alteplase in two patients thrombolysed for stroke.

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