Yin ZhiQiang, Xu JiaLi, Li YongQiang, Xia JiPing, Luo Dan
Department of Dermatology The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
Department of Oncology The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
Drug Des Devel Ther. 2014 Sep 2;8:1231-3. doi: 10.2147/DDDT.S66868. eCollection 2014.
This study reports a case of an 80-year-old male who suffered from drug eruption due to oral allopurinol for the treatment of gout. This patient complained of widespread erythema and maculopapule with itch, and small quantities of purplish-red rash with diffused distribution on four limbs were noted. After he was hospitalized, the area with purpuric rash increased in size, and hypofibrinogenemia was found. After treatment with intravenous infusion of fibrinogen and cryoprecipitate, and continued treatment with high-dose methylprednisolone, the skin rash gradually went away. This is the first report of purpura and hypofibrinogenemia induced by allopurinol and the pathophysiology underlying this reaction remained unknown.
本研究报告了一例80岁男性患者，因口服别嘌醇治疗痛风而发生药物疹。该患者主诉全身出现红斑和斑丘疹伴瘙痒，四肢可见少量紫红色皮疹，呈弥漫性分布。住院后，紫癜性皮疹面积增大，并发现纤维蛋白原血症。经静脉输注纤维蛋白原和冷沉淀治疗，并继续使用大剂量甲泼尼龙治疗后，皮疹逐渐消退。这是别嘌醇诱发紫癜和纤维蛋白原血症的首例报告，该反应的病理生理学机制尚不清楚。
