El Amrani F, Meknassi I, Bouaddi M, Raffas W, Kettani F, Senouci K, Hassam B
Service de dermatologie-vénéréologie, CHU Ibn Sina, Rabat-instituts, rue Famfdal-Cherkaoui, BP 6527, Rabat, Maroc.
Ann Dermatol Venereol. 2012 Nov;139(11):723-6. doi: 10.1016/j.annder.2012.05.009. Epub 2012 Jun 19.
Seborrhoeic keratoses (SK) are benign tumours preferentially located on the head and trunk. We report a case of giant SK at an unusual site.
An 85-year-old man consulted for pigmented genital lesions present for 10 years. Clinical examination revealed small pigmented formations evoking SK and other pigmented, confluent and hyperkeratotic bordering plaques with a circinate contour. The latter lesions were biopsied, and histological findings were characteristic of SK and showed epidermal acanthosis associated with orthokeratotic invagination of the mucosa, resulting in the formation of characteristic wells. Treatment by electrocoagulation curettage was undertaken.
SK are benign tumours that occur primarily in patients aged over 50 years. They are preferentially located in the trunk, head and neck. A genital site of SK is very unusual, with no more than 10 published cases. The cause of genital SK is as yet unknown, but data in the literature point to a possible role of chronic friction and HPV.
脂溢性角化病（SK）是一种良性肿瘤，好发于头颈部和躯干。我们报告一例发生于不寻常部位的巨大SK病例。
一名85岁男性因生殖器色素沉着病变就诊，病程10年。临床检查发现有小的色素沉着皮损，提示为SK，还有其他色素沉着、融合且边界呈环状的角化过度斑块。对后者进行活检，组织学结果符合SK特征，显示表皮棘层增厚，伴有黏膜正角化内陷，形成特征性的陷窝。采用电凝刮除术进行治疗。
SK是主要发生于50岁以上患者的良性肿瘤。好发于躯干、头颈部。SK发生于生殖器部位非常罕见，文献报道不超过10例。生殖器SK的病因尚不清楚，但文献资料提示慢性摩擦和人乳头瘤病毒（HPV）可能起作用。
