Zhang Min, Huang Bing
Stem Cell Res Ther. 2012 Nov 30;3(6):48. doi: 10.1186/scrt139.
Peripheral blood is a large accessible source of adult stem cells for both basic research and clinical applications. Peripheral blood mononuclear cells (PBMCs) have been reported to contain a multitude of distinct multipotent progenitor cell populations and possess the potential to differentiate into blood cells, endothelial cells, hepatocytes, cardiomyogenic cells, smooth muscle cells, osteoblasts, osteoclasts, epithelial cells, neural cells, or myofibroblasts under appropriate conditions. Furthermore, transplantation of these PBMC-derived cells can regenerate tissues and restore function after injury. This mini-review summarizes the multi-differentiation potential of PBMCs reported in the past years, discusses the possible mechanisms for this multi-differentiation potential, and describes recent techniques for efficient PBMC isolation and purification.
外周血是用于基础研究和临床应用的大量可获取的成体干细胞来源。据报道，外周血单个核细胞（PBMCs）包含多种不同的多能祖细胞群体，并具有在适当条件下分化为血细胞、内皮细胞、肝细胞、心肌细胞、平滑肌细胞、成骨细胞、破骨细胞、上皮细胞、神经细胞或肌成纤维细胞的潜力。此外，这些PBMC来源的细胞移植后可使组织再生并在损伤后恢复功能。本综述总结了过去几年报道的PBMCs的多分化潜能，讨论了这种多分化潜能的可能机制，并描述了高效PBMC分离和纯化的最新技术。
