M2rlab-XCELL, 28010 Madrid, Spain.
Department of Experimental Pathology, Instituto de Investigaciones Biomédicas de Barcelona-Consejo Superior de Investigaciones Científicas Institut d'Investigacions Biomèdiques August Pi i Sunyer (IIBB-CSIC-IDIBAPS), 08036 Barcelona, Spain.
Int J Mol Sci. 2022 Dec 15;23(24):15943. doi: 10.3390/ijms232415943.
The incidence of renal disease is gradually increasing worldwide, and this condition has become a major public health problem because it is a trigger for many other chronic diseases. Cell therapies using multipotent mesenchymal stromal cells, hematopoietic stem cells, macrophages, and other cell types have been used to induce regeneration and provide a cure for acute and chronic kidney disease in experimental models. This review describes the advances in cell therapy protocols applied to acute and chronic kidney injuries and the attempts to apply these treatments in a clinical setting.
全球范围内，肾病的发病率逐渐上升，这种情况已成为一个主要的公共卫生问题，因为它是许多其他慢性疾病的诱因。利用多能间充质基质细胞、造血干细胞、巨噬细胞和其他细胞类型的细胞疗法已被用于诱导肾脏再生，并为急性和慢性肾病的实验模型提供治疗。本综述描述了应用于急性和慢性肾损伤的细胞治疗方案的进展，以及尝试将这些治疗方法应用于临床的情况。
