Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Neurosci Lett. 2013 Jan 15;533:50-4. doi: 10.1016/j.neulet.2012.11.020. Epub 2012 Nov 28.
Expression of hippocampal glucocorticoid receptors (GRs) and spatial learning and memory were observed in rat model of diffuse traumatic brain injury (TBI) due to lateral head acceleration with an aim at investigating the relation between GRs expression and cognitive deficits. Immunohistochemical staining, Western blotting, and RT-PCR indicated that down-regulation of GRs expression occurred in the hippocampus among TBI-rats which demonstrated reduced performance of learning and memory in Morris water maze. As the GRs expression bounced up, the cognitive function approached to normal. It is concluded that reduced expression of hippocampal GRs was closely associated with learning and memory deficits in TBI-rats. Hippocampal GRs was involved in the biochemical mechanisms of cognitive deficits after TBI.
观察到由于头部侧向加速导致的弥漫性创伤性脑损伤（TBI）大鼠模型中海马糖皮质激素受体（GRs）的表达和空间学习记忆，目的是研究 GRs 表达与认知缺陷之间的关系。免疫组织化学染色、Western blot 和 RT-PCR 表明，TBI 大鼠海马中 GRs 表达下调，在 Morris 水迷宫中表现出学习和记忆能力下降。随着 GRs 表达的增加，认知功能逐渐恢复正常。结论：海马 GRs 的表达减少与 TBI 大鼠的学习和记忆缺陷密切相关。海马 GRs 参与了 TBI 后认知缺陷的生化机制。
