Sen D, Gilbert W
Department of Cellular and Development Biology, Harvard University, Cambridge, Massachusetts 02138.
Nature. 1990 Mar 29;344(6265):410-4. doi: 10.1038/344410a0.
Single-stranded complex guanine-rich DNA sequences from chromosomal telomeres and elsewhere can associate to form stable parallel four-stranded structures termed G4-DNA by a process that is anomalously dependent on the particular alkali metal cation that is present. The anomaly, which is not found in the formation of G4-DNA by oligonucleotides containing short, single runs of three or more guanines, is caused by potassium cations excessively stabilizing fold-back intermediate structures, or pathway by-products.
来自染色体端粒及其他部位的富含鸟嘌呤的单链复杂DNA序列可通过一个异常依赖于所存在的特定碱金属阳离子的过程相互结合，形成被称为G4-DNA的稳定平行四链结构。这种异常现象在由含有短的、连续三个或更多鸟嘌呤的寡核苷酸形成G4-DNA的过程中未被发现，它是由钾离子过度稳定折返中间结构或途径副产物所导致的。
