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男性骨质疏松症的治疗。

Treatment of osteoporosis in men.

机构信息

Department of Endocrinology and Unit for Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital, De pintelaan 185, B9000 Gent, Belgium.

出版信息

Bone. 2013 Mar;53(1):134-44. doi: 10.1016/j.bone.2012.11.018. Epub 2012 Nov 28.

Abstract

SUMMARY

Aspects of osteoporosis in men, such as screening and identification strategies, definitions of diagnosis and intervention thresholds, and treatment options (both approved and in the pipeline) are discussed.

INTRODUCTION

Awareness of osteoporosis in men is improving, although it remains under-diagnosed and under-treated. A European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) workshop was convened to discuss osteoporosis in men and to provide a report by a panel of experts (the authors).

METHODS

A debate with an expert panel on preselected topics was conducted.

RESULTS AND CONCLUSIONS

Although additional fracture data are needed to endorse the clinical care of osteoporosis in men, consensus views were reached on diagnostic criteria and intervention thresholds. Empirical data in men display similarities with data acquired in women, despite pathophysiological differences, which may not be clinically relevant. Men should receive treatment at a similar 10-year fracture probability as in women. The design of mixed studies may reduce the lag between comparable treatments for osteoporosis in women becoming available in men.

摘要

总结

讨论了男性骨质疏松症的各个方面,如筛查和识别策略、诊断和干预阈值的定义以及治疗选择(包括已批准和正在研发中的选择)。

引言

尽管男性骨质疏松症的诊断和治疗仍不足,但人们对其的认识正在提高。召开了一个欧洲临床和经济骨质疏松症和骨关节炎学会(ESCEO)研讨会,以讨论男性骨质疏松症,并由专家组(作者)提供一份报告。

方法

对预先选定的主题进行了一场专家小组辩论。

结果与结论

尽管需要更多的骨折数据来支持男性骨质疏松症的临床护理,但在诊断标准和干预阈值方面达成了共识。尽管存在病理生理学差异,但男性的经验数据与女性获得的数据相似,这些差异可能在临床上并不相关。男性应按照与女性相似的 10 年骨折概率接受治疗。混合研究的设计可能会减少女性骨质疏松症的可比治疗方法在男性中应用的滞后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0fc/3662207/916dc9fd3ad5/emss-53249-f0001.jpg

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