Department of Clinical Laboratory, Juntendo University Hospital, Tokyo, Japan.
J Hosp Infect. 2013 Feb;83(2):153-5. doi: 10.1016/j.jhin.2012.10.005. Epub 2012 Nov 30.
The objective of this study was to explore independent risk factors for the isolation of multidrug-resistant (MDR) Pseudomonas aeruginosa in a Japanese university hospital between January 1997 and December 2010. MDR P. aeruginosa was defined when the organism was resistant or intermediately susceptible to all five antimicrobials tested. In all, 159 patients with MDR P. aeruginosa were identified over the 14-year period. Multivariate logistic regression analysis revealed that prolonged hospital stay, prior exposure to meropenem and fluoroquinolones, and patients suffering from diabetes mellitus or receiving surgery were predictive risk factors for the isolation of MDR P. aeruginosa.
本研究旨在探讨 1997 年 1 月至 2010 年 12 月期间日本某大学医院分离出的多重耐药（MDR）铜绿假单胞菌的独立危险因素。MDR 铜绿假单胞菌的定义为该菌对所有五种测试的抗菌药物均表现出耐药或中介敏感性。在 14 年期间共发现 159 例 MDR 铜绿假单胞菌患者。多变量 logistic 回归分析显示，住院时间延长、先前接触美罗培南和氟喹诺酮类药物以及患有糖尿病或接受手术的患者是分离出 MDR 铜绿假单胞菌的预测危险因素。
