Lab of Controlled Release and Drug Delivery System, College of Pharmaceutical Sciences, Soochow University, Suzhou 215000, China.
Department of Pharmacy, Abdul Wali Khan University Mardan, Mardan 23200, Pakistan.
Curr Drug Targets. 2024;25(10):670-682. doi: 10.2174/0113894501302098240430164446.
Diabetes Mellitus (DM) is referred to as hyperglycemia in either fasting or postprandial phases. Oxidative stress, which is defined by an excessive amount of reactive oxygen species (ROS) production, increased exposure to external stress, and an excessive amount of the cellular defense system against them, results in cellular damage. Increased DNA damage is one of the main causes of genomic instability, and genetic changes are an underlying factor in the emergence of cancer. Through covalent connections with DNA and proteins, quercetin has been demonstrated to offer protection against the creation of oxidative DNA damage. It has been found that quercetin shields DNA from possible oxidative stress-related harm by reducing the production of ROS. Therefore, Quercetin helps to lessen DNA damage and improve the ability of DNA repair mechanisms. This review mainly focuses on the role of quercetin in repairing DNA damage and compensating for drug resistance in diabetic patients. Data on the target topic was obtained from major scientific databases, including SpringerLink, Web of Science, Google Scholar, Medline Plus, PubMed, Science Direct, and Elsevier. In preclinical studies, quercetin guards against DNA deterioration by regulating the degree of lipid peroxidation and enhancing the antioxidant defense system. By reactivating antioxidant enzymes, decreasing ROS levels, and decreasing the levels of 8-hydroxydeoxyguanosine, Quercetin protects DNA from oxidative damage. In clinical studies, it was found that quercetin supplementation was related to increased antioxidant capacity and decreased risk of type 2 diabetes mellitus in the experimental group as compared to the placebo group. It is concluded that quercetin has a significant role in DNA repair in order to overcome drug resistance in diabetes.
糖尿病（DM）是指空腹或餐后阶段的高血糖症。氧化应激是指活性氧（ROS）产生过多、外部应激增加以及细胞防御系统对其过度反应，导致细胞损伤。DNA 损伤增加是基因组不稳定的主要原因之一，遗传变化是癌症发生的一个潜在因素。槲皮素通过与 DNA 和蛋白质形成共价键，已被证明可以防止氧化 DNA 损伤的产生。研究发现，槲皮素可以通过减少 ROS 的产生来保护 DNA 免受可能与氧化应激相关的伤害。因此，槲皮素有助于减轻 DNA 损伤并提高 DNA 修复机制的能力。本综述主要关注槲皮素在修复糖尿病患者的 DNA 损伤和补偿药物耐药性方面的作用。关于目标主题的数据来自主要的科学数据库，包括 SpringerLink、Web of Science、Google Scholar、Medline Plus、PubMed、Science Direct 和 Elsevier。在临床前研究中，槲皮素通过调节脂质过氧化程度和增强抗氧化防御系统来保护 DNA 免受恶化。通过重新激活抗氧化酶、降低 ROS 水平和降低 8-羟基脱氧鸟苷水平，槲皮素可以防止 DNA 受到氧化损伤。在临床研究中，与安慰剂组相比，发现补充槲皮素与实验组的抗氧化能力增加和 2 型糖尿病风险降低有关。因此，为了克服糖尿病中的药物耐药性，槲皮素在 DNA 修复中具有重要作用。
