Department of Chemistry, Faculty of Science, University of Guilan, Namjoo Street, PO Box: 1914, Rasht, Iran.
Colloids Surf B Biointerfaces. 2013 Mar 1;103:84-93. doi: 10.1016/j.colsurfb.2012.10.024. Epub 2012 Oct 23.
A novel, simple and selective electrochemical method was investigated for the single or simultaneous determination of tyrosine (Tyr) and paracetamol (PC) in aqueous media (phosphate buffer solution, pH 7.5) on MWCNTs-graphene nanosheet nanocomposite modified glassy carbon electrode (MWCNTs-GNS/GCE) using differential pulse voltammetry (DPV). The MWCNTs-GNS/GCE displayed high effective surface area, high porosity, more reactive sites and excellent electrochemical catalytic activity toward the oxidation of Tyr and PC. The peak current of differential pulse voltammograms of Tyr and PC increased linearly with their concentration in the ranges of 0.90-95.4 μM Tyr and 0.80-110.0 μM PC. The detection limits for Tyr and PC were 0.19 μM and 0.10 μM, respectively. The proposed sensor was successfully applied for the determination of Tyr and PC in human blood serum and pharmaceutical samples.
研究了一种新颖、简单、选择性的电化学方法，用于在水介质（磷酸盐缓冲溶液，pH 7.5）中在 MWCNTs-石墨烯纳米片纳米复合材料修饰的玻碳电极（MWCNTs-GNS/GCE）上使用差分脉冲伏安法（DPV）对酪氨酸（Tyr）和扑热息痛（PC）进行单一或同时测定。MWCNTs-GNS/GCE 显示出高有效表面积、高孔隙率、更多反应位点和对 Tyr 和 PC 氧化的优异电化学催化活性。差分脉冲伏安法中 Tyr 和 PC 的峰电流随其浓度在 0.90-95.4 μM Tyr 和 0.80-110.0 μM PC 范围内呈线性增加。Tyr 和 PC 的检测限分别为 0.19 μM 和 0.10 μM。该传感器成功应用于人血清和药物样品中 Tyr 和 PC 的测定。
